Physical Sciences and Mathematics Commons^™

A Mechanistic Study Of Micro Rna 21 Induced Hepatic Fibrosis And Use Of Sparstolonin B In Remediation Of Environmental Nafld, Diptadip Dattaroy

Theses and Dissertations

Due to the increased prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) has become a major public health problem in the Western world and Asian countries. Approximately a third of the general population in the US has NAFLD. NAFLD includes a spectrum of histological characteristics ranging from simple steatosis to steatohepatitis, fibrosis and cirrhosis and can be characterized into to two major phenotypes: nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Water disinfection byproducts like trihalomethanes can act as crucial risk factors for NAFLD progression. Here I have studied the molecular mechanisms of a water disinfection byproduct, Bromodichloromethane, in induction …