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Full-Text Articles in Physical Sciences and Mathematics
Weight Of Evidence Evaluation Of A Network Of Adverse Outcome Pathways Linking Activation Of The Nicotinic Acetylcholine Receptor In Honey Bees To Colony Death, Carlie A. Lalone, Daniel L. Villeneuve, Judy Wu-Smart, Rebecca Y. Milsk, Keith Sappington, Kristina V. Garber, Justin Housenger, Gerald T. Ankley
Weight Of Evidence Evaluation Of A Network Of Adverse Outcome Pathways Linking Activation Of The Nicotinic Acetylcholine Receptor In Honey Bees To Colony Death, Carlie A. Lalone, Daniel L. Villeneuve, Judy Wu-Smart, Rebecca Y. Milsk, Keith Sappington, Kristina V. Garber, Justin Housenger, Gerald T. Ankley
United States Environmental Protection Agency: Staff Publications
Ongoing honey bee (Apis mellifera) colony losses are of significant international concern because of the essential role these insects play in pollinating crops. Both chemical and non-chemical stressors have been implicated as possible contributors to colony failure; however, the potential role(s) of commonly-used neonicotinoid insecticides has emerged as particularly concerning. Neonicotinoids act on the nicotinic acetylcholine receptors (nAChRs) in the central nervous system to eliminate pest insects. However, mounting evidence indicates that neonicotinoids also may adversely affect beneficial pollinators, such as the honey bee, via impairments on learning and memory, and ultimately foraging success. The specificmechanisms linking activation …
Adverse Outcome Pathways And Ecological Risk Assessment: Bridging To Population-Level Effects, Vincent J. Kramer, Matthew A. Etterson, Markus Hecker, Cheryl A. Murphy, Guritno Roesijadi, Daniel J. Spade, Julann A. Spromberg, Magnus Wang, Gerald T. Ankley
Adverse Outcome Pathways And Ecological Risk Assessment: Bridging To Population-Level Effects, Vincent J. Kramer, Matthew A. Etterson, Markus Hecker, Cheryl A. Murphy, Guritno Roesijadi, Daniel J. Spade, Julann A. Spromberg, Magnus Wang, Gerald T. Ankley
United States Environmental Protection Agency: Staff Publications
Maintaining the viability of populations of plants and animals is a key focus for environmental regulation. Population-level responses integrate the cumulative effects of chemical stressors on individuals as those individuals interact with and are affected by their conspecifics, competitors, predators, prey, habitat, and other biotic and abiotic factors. Models of population-level effects of contaminants can integrate information from lower levels of biological organization and feed that information into higher-level community and ecosystem models. As individual-level endpoints are used to predict population responses, this requires that biological responses at lower levels of organization be translated into a form that is usable …