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Full-Text Articles in Physical Sciences and Mathematics
Multipoint Spectroscopy And Stereoscopic Imaging Of Pharmaceutical Particles, Hicham Rifai
Multipoint Spectroscopy And Stereoscopic Imaging Of Pharmaceutical Particles, Hicham Rifai
Masters
Particle and granule properties play a key role in the final product quality of pharmaceuticals. Thus the identification and monitoring of key chemical and physical parameters is essential in the production of pharmaceuticals. The existing off-line methods are generally slow and labour intensive. Near infra-red (NIR) multipoint spectroscopy and image analysis are an attractive alternative compared to the traditional methods because they are both nondestructive and non-interfering allowing the analysis in real time of particles physical and chemical properties. This research is a preliminary study performed at laboratory scale and aims at developing chemometric and imaging algorithms for real time …
Computational Development Of Selective Nnos Inhibitors: Binding Modes And Pharmacokinetic Considerations, Adam Curtin, Gemma K. Kinsella, John Stephens
Computational Development Of Selective Nnos Inhibitors: Binding Modes And Pharmacokinetic Considerations, Adam Curtin, Gemma K. Kinsella, John Stephens
Articles
Abstract: Neuronal nitric oxide synthase (nNOS) produces the key signalling mediator nitric oxide, (NO). This gaseous, free radical molecule modulates a vast array of biological processes, from vascular pressure to immune responses and neurological signalling cascades. Overproduction of NO has been implicated in conditions including Alzheimer’s disease, Parkinson’s disease and schizophrenia. Inhibition of nNOS therefore offers a potential therapeutic approach for treatment of these conditions. This endeavour is made more complex by the fact that there are two other isoforms of nitric oxide synthase (NOS), endothelial NOS (eNOS) and inducible NOS (iNOS). The selectivity of nNOS inhibitors is therefore a …