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Articles 1 - 5 of 5
Full-Text Articles in Physical Sciences and Mathematics
2018 Ieee Signal Processing Cup: Forensic Camera Model Identification Challenge, Michael Geiger
2018 Ieee Signal Processing Cup: Forensic Camera Model Identification Challenge, Michael Geiger
Honors Theses
The goal of this Senior Capstone Project was to lead Union College’s first ever Signal Processing Cup Team to compete in IEEE’s 2018 Signal Processing Cup Competition. This year’s competition was a forensic camera model identification challenge and was divided into two separate stages of competition: Open Competition and Final Competition. Participation in the Open Competition was open to any teams of undergraduate students, but the Final Competition was only open to the three finalists from Open Competition and is scheduled to be held at ICASSP 2018 in Calgary, Alberta, Canada. Teams that make it to the Final Competition will …
Optimization Of Superhydrophobic Surface Production Using Ambient-Dried Silica-Based Aerogels, Elizabeth Donlon
Optimization Of Superhydrophobic Surface Production Using Ambient-Dried Silica-Based Aerogels, Elizabeth Donlon
Honors Theses
Superhydrophobic surfaces exhibit particular properties that make them functional in various anti-sticking, anti-contamination, self-cleaning and drag reduction applications. Though such surfaces are found in nature - most notably the lotus leaf - they are difficult to produce. There are numerous methods and techniques for fabricating superhydrophobic surfaces. One such method is the sol-gel method, in which aerogel, a highly porous and lightweight material that can be made hydrophobic or superhydrophobic, is coated onto a surface. The purpose of this project is to devise a simple and repeatable procedure for making hydrophobic silica aerogel coatings that can be used for drag …
Biocompatible, Responsive Polysoaps Via Raft Copolymerization For The Delivery Of Model Cancer Therapeutics, Mason Dearborn
Biocompatible, Responsive Polysoaps Via Raft Copolymerization For The Delivery Of Model Cancer Therapeutics, Mason Dearborn
Honors Theses
Many chemotherapeutic drugs are small, hydrophobic molecules that require water-soluble, biocompatible nanocarriers for enhanced vascular circulation. Existing polymeric carriers either conjugate the drug along a copolymer backbone or sequester drugs within a protected interior domain to be delivered to specific sites in the body. Such therapeutic systems must overcome a myriad of hurdles, beginning with complex, multi-step syntheses, followed by other inherent barriers that limit the efficiency of drug delivery at the targeted site. This work aims to circumvent a number of these issues using biocompatible, stimuli-responsive polysoaps that are capable of unimeric micelle formation, hydrophobic drug delivery, and triggered …
O-Glcnac Post Translational Modification Of Hypoxia-Inducible Factor (Hif) Proteins, Hailey Elisabeth Grisham
O-Glcnac Post Translational Modification Of Hypoxia-Inducible Factor (Hif) Proteins, Hailey Elisabeth Grisham
Honors Theses
O-linked β-N-acetylglucosamine (O-GlcNAc) post-translational modification (O- GlcNAcylation), plays a vital role in many metabolic pathways, including those of numerous diseases. New research methods and basic functional roles of O-GlcNAc post- translational modification on metabolism, human health, and cancer are quickly developing, but a vast amount of research remains on the specificity of this pathway towards specific proteins. In this study, T47D breast cancer cells were used as an in vitro model to investigate the effects of O-GlcNAc modification on hypoxia-inducible factor (HIF) proteins.
Targeting Metastatic Breast Cancer With Statin Drugs And Coq10, Jacob Thrasher
Targeting Metastatic Breast Cancer With Statin Drugs And Coq10, Jacob Thrasher
Honors Theses
Statin drugs are commonly prescribed to lower cholesterol levels in patients, but recently statins have been under investigation as a potential anti-cancer drug. Statins are HMG-CoA reductase inhibitors and subsequently inhibit the mevalonate pathway and cholesterol synthesis. Since cholesterol trafficking is vital in the growth and metastasis of cancer, statin drugs are being studied to explore their effects on cancer cells. CoQ10, one of the products from the mevalonate pathway, also has shown some potential anti-cancer properties, but its use to combat cancer is controversial. While some studies have shown that CoQ10 supplements can be synergistic with other cancer treatment …