Physical Sciences and Mathematics Commons^™

Algorithmic Robot Design: Label Maps, Procrustean Graphs, And The Boundary Of Non-Destructiveness, Shervin Ghasemlou

Theses and Dissertations

This dissertation is focused on the problem of algorithmic robot design. The process of designing a robot or a team of robots that can reliably accomplish a task in an environment requires several key elements. How the problem is formulated can play a big role in the design process. The ability of the model to correctly reflect the environment, the events, and different pieces of the problem is crucial. Another key element is the ability of the model to show the relationship between different designs of a single system. These two elements can enable design algorithms to navigate through the …

Quasinovo: Algorithms For De Novo Peptide Sequencing, James Paul Cleveland

Theses and Dissertations

High-throughput proteomics analysis involves the rapid identification and characterization of large sets of proteins in complex biological samples. Tandem mass spectrometry (MS/MS) has become the leading approach for the experimental identification of proteins. Accurate analysis of the data produced is a computationally challenging process that relies on a complex understanding of molecular dynamics, signal processing, and pattern classification. In this work we address these modeling and classification problems, and introduce an additional data-driven evolutionary information source into the analysis pipeline.

The particular problem being solved is peptide sequencing via MS/MS. The objective in solving this problem is to decipher the …