Physical Sciences and Mathematics Commons^™

Using An Integrative Machine Learning Approach To Study Microrna Regulation Networks In Pancreatic Cancer Progression, Roland Madadjim

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

With advances in genomic discovery tools, recent biomedical research has produced a massive amount of genomic data on post-transcriptional regulations related to various transcript factors, microRNAs, lncRNAs, epigenetic modifications, and genetic variations. In this direction, the field of gene regulation network inference is created and aims to understand the interactome regulations between these molecules (e.g., gene-gene, miRNA-gene) that take place to build models able to capture behavioral changes in biological systems. A question of interest arises in integrating such molecules to build a network while treating each specie in its uniqueness. Given the dynamic changes of interactome in chaotic systems …