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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
Identifying Key Activity Indicators In Rats' Neuronal Data Using Lasso Regularized Logistic Regression, Avery Woods
Identifying Key Activity Indicators In Rats' Neuronal Data Using Lasso Regularized Logistic Regression, Avery Woods
Honors Theses
This thesis aims to identify timestamps of rats’ neuronal activity that best determine behavior using a machine learning model. Neuronal data is a complex and high-dimensional dataset, and identifying the most informative features is crucial for understanding the underlying neuronal processes. The Lasso regularization technique is employed to select the most relevant features of the data to the model’s prediction. The results of this study provide insights into the key activity indicators that are associated with specific behaviors or cognitive processes in rats, as well as the effect that stress can have on neuronal activity and behavior. Ultimately, it was …
Parametric Design Of Flywheel For An Electric Punch Press, Prashant Dhakal
Parametric Design Of Flywheel For An Electric Punch Press, Prashant Dhakal
Honors Theses
Almost all designs start with a design requirement. These may be weight, volume, clearance, and even custom calculations. Finding a solution that meets these requirements often involves tedious and time-consuming iterations. Once the solution has been found, the design must be optimized to find the best possible solution. Finding the ‘best possible design’ requires substantial time and effort dedicated to iterating and analyzing the potential model solutions. This is where Parametric design comes into play. The Parametric design aids in specifying the key parameters of the design and makes changes interactively, with the model updating automatically. The purpose of this …
Heel Down And Toe-Off Time Measured With Ultrasonic Doppler System And Force Plate Sensor, Sabin Timsina
Heel Down And Toe-Off Time Measured With Ultrasonic Doppler System And Force Plate Sensor, Sabin Timsina
Honors Theses
Collie Box is a medical device that measures the gait parameters of the person walk- ing in front of it. This device uses the Ultrasonic Doppler system to extract the heel-contact and toe-off times of a person walking within the range of 2-10 meters. These times are used to determine the leg’s swing phase and double stance times. The ultrasonic transducer of 10mm diameter is driven at 40kHz. At the time of the heel-contact and toe-off, foot velocity is zero while the torso part of the human body is still in motion. The wide directivity of 10mm diameter ultrasonic transducer …
Investigatin Actin-Myosin Mechanics To Model Heart Disease Using Fluorescence Microscopy And Optical Trapping, Justin Edward Reynolds
Investigatin Actin-Myosin Mechanics To Model Heart Disease Using Fluorescence Microscopy And Optical Trapping, Justin Edward Reynolds
Honors Theses
Hypertrophic cardiomyopathy (HCM) is a hereditary disease in which the myocardium becomes hypertrophied, making it more difficult for the heart to pump blood. HCM is commonly caused by a mutation in the β-cardiac myosin II heavy chain. Myosin is a motor protein that facilitates muscle contraction by converting chemical energy from ATP hydrolysis into mechanical work and concomitantly moving along actin filaments. Optical tweezers have been used previously to analyze single myosin biophysical properties; however, myosin does not work as a single unit within the heart. Multiple myosin interacts to displace actin filaments and do not have the same properties …
O-Glcnac Post Translational Modification Of Hypoxia-Inducible Factor (Hif) Proteins, Hailey Elisabeth Grisham
O-Glcnac Post Translational Modification Of Hypoxia-Inducible Factor (Hif) Proteins, Hailey Elisabeth Grisham
Honors Theses
O-linked β-N-acetylglucosamine (O-GlcNAc) post-translational modification (O- GlcNAcylation), plays a vital role in many metabolic pathways, including those of numerous diseases. New research methods and basic functional roles of O-GlcNAc post- translational modification on metabolism, human health, and cancer are quickly developing, but a vast amount of research remains on the specificity of this pathway towards specific proteins. In this study, T47D breast cancer cells were used as an in vitro model to investigate the effects of O-GlcNAc modification on hypoxia-inducible factor (HIF) proteins.
Targeting Metastatic Breast Cancer With Statin Drugs And Coq10, Jacob Thrasher
Targeting Metastatic Breast Cancer With Statin Drugs And Coq10, Jacob Thrasher
Honors Theses
Statin drugs are commonly prescribed to lower cholesterol levels in patients, but recently statins have been under investigation as a potential anti-cancer drug. Statins are HMG-CoA reductase inhibitors and subsequently inhibit the mevalonate pathway and cholesterol synthesis. Since cholesterol trafficking is vital in the growth and metastasis of cancer, statin drugs are being studied to explore their effects on cancer cells. CoQ10, one of the products from the mevalonate pathway, also has shown some potential anti-cancer properties, but its use to combat cancer is controversial. While some studies have shown that CoQ10 supplements can be synergistic with other cancer treatment …