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Full-Text Articles in Physical Sciences and Mathematics
Multi-Echo Quantitative Susceptibility Mapping For Strategically Acquired Gradient Echo (Stage) Imaging, Sara Gharabaghi, Saifeng Liu, Ying Wang, Yongsheng Chen, Sagar Buch, Mojtaba Jokar, Thomas Wischgoll, Nasser H. Kashou, Chunyan Zhang, Bo Wu, Jingliang Cheng, E. Mark Haacke
Multi-Echo Quantitative Susceptibility Mapping For Strategically Acquired Gradient Echo (Stage) Imaging, Sara Gharabaghi, Saifeng Liu, Ying Wang, Yongsheng Chen, Sagar Buch, Mojtaba Jokar, Thomas Wischgoll, Nasser H. Kashou, Chunyan Zhang, Bo Wu, Jingliang Cheng, E. Mark Haacke
Computer Science and Engineering Faculty Publications
Purpose: To develop a method to reconstruct quantitative susceptibility mapping (QSM) from multi-echo, multi-flip angle data collected using strategically acquired gradient echo (STAGE) imaging. Methods: The proposed QSM reconstruction algorithm, referred to as “structurally constrained Susceptibility Weighted Imaging and Mapping” scSWIM, performs an ℓ1 and ℓ2 regularization-based reconstruction in a single step. The unique contrast of the T1 weighted enhanced (T1WE) image derived from STAGE imaging was used to extract reliable geometry constraints to protect the basal ganglia from over-smoothing. The multi-echo multi-flip angle data were used for improving the contrast-to-noise ratio in QSM through a weighted averaging scheme. The …
Quantitative Susceptibility Mapping (Qsm) Reconstruction From Mri Phase Data, Sara Gharabaghi
Quantitative Susceptibility Mapping (Qsm) Reconstruction From Mri Phase Data, Sara Gharabaghi
Browse all Theses and Dissertations
Quantitative susceptibility mapping (QSM) is a powerful technique that reveals changes in the underlying tissue susceptibility distribution. It can be used to measure the concentrations of iron and calcium in the brain both of which are linked with numerous neurodegenerative diseases. However, reconstructing the QSM image from the MRI phase data is an ill-posed inverse problem. Different methods have been proposed to overcome this difficulty. Still, the reconstructed QSM images suffer from streaking artifacts and underestimate the measured susceptibility of deep gray matter, veins, and other high susceptibility regions. This thesis proposes a structurally constrained Susceptibility Weighted Imaging and Mapping …