Physical Sciences and Mathematics Commons^™

Computer-Aided Classification Of Impulse Oscillometric Measures Of Respiratory Small Airways Function In Children, Nancy Selene Avila

Open Access Theses & Dissertations

Computer-aided classification of respiratory small airways dysfunction is not an easy task. There is a need to develop more robust classifiers, specifically for children as the classification studies performed to date have the following limitations: 1) they include features derived from tests that are not suitable for children and 2) they cannot distinguish between mild and severe small airway dysfunction.

This Dissertation describes the classification algorithms with high discriminative capacity to distinguish different levels of respiratory small airways function in children (Asthma, Small Airways Impairment, Possible Small Airways Impairment, and Normal lung function). This ability came from innovative feature selection, …

Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal

Theses and Dissertations--Computer Science

Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying other essential relations (e.g., causation, prevention) between biomedical entities is also critical to understand biomedical processes. Hence, it is crucial to develop automated relation prediction systems that can yield plausible biomedical relations to expedite the discovery process. In this dissertation, we demonstrate three approaches to predict treatment relations between biomedical entities for the drug repositioning task …