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The Influence Of Tributyltin On Various Aspects Of Activation And Reactive Oxygen Formation In Oyster Toadfish (Opsanus Tau) Macrophages, Charles D. Rice
The Influence Of Tributyltin On Various Aspects Of Activation And Reactive Oxygen Formation In Oyster Toadfish (Opsanus Tau) Macrophages, Charles D. Rice
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The effects of tributyltin (TBT) on phorbol myristate acetate (PMA)- and calcium ionophore (A23187)-stimulated peritoneal macrophages from oyster toadfish (Opsanus tau) were evaluated in a luminol-dependent chemiluminescence (CL) assay. PMA-stimulated CL responses were increased by in vitro exposure to 50 ug/L TBT, but depressed to baseline values by 500 ug/L TBT. A23187-stimulated CL increased with 5 ug/L and 50 ug/L TBT, and depressed by 500 ug/L TBT. Responses stimulated by synergistic doses of PMA and A23187 were increased by 50 ug/L TBT and depressed by 500 ug/L TBT. Enhanced PMA- and A23187-stimulated CL following TBT exposure returned to baseline values …