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Full-Text Articles in Physical Sciences and Mathematics
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Dissertations, Theses, and Capstone Projects
The cost of bringing a drug to market is astounding and the failure rate is intimidating. Drug discovery has been of limited success under the conventional reductionist model of one-drug-one-gene-one-disease paradigm, where a single disease-associated gene is identified and a molecular binder to the specific target is subsequently designed. Under the simplistic paradigm of drug discovery, a drug molecule is assumed to interact only with the intended on-target. However, small molecular drugs often interact with multiple targets, and those off-target interactions are not considered under the conventional paradigm. As a result, drug-induced side effects and adverse reactions are often neglected …
Sensor Data Analysis In Smart Buildings, Manuel A. Mane Penton
Sensor Data Analysis In Smart Buildings, Manuel A. Mane Penton
Publications and Research
Data analysis and Machine Learning are destined to evolve the current technology infrastructure by solving technology and economy demands present mainly in developed cities like New York. This research proposes a machine learning (ML) based solution to alleviate one of the main issues that big buildings such as CUNY campuses have, that is the waste of energy resources. The analysis of data coming from the readings of different deployed sensors such as CO2, humidity and temperature can be used to estimate occupancy in a specific room and building in general. The outcome of this research established a relationship between the …