Physical Sciences and Mathematics Commons^™

Investigation Of Temperature Dependent Magnetic Hyperthermia In Fe3o4 Ferrofluids, Humeshkar Bhaskar Nemala

Wayne State University Dissertations

Magnetic nanoparticles (MNPs) of Fe3O4 and gamma-Fe2O3 have been exploited in the biomedical fields for imaging, targeted drug delivery and magnetic hyperthermia. Magnetic hyperthermia (MHT), the production of heat using ferrofluids, colloidal suspensions of MNPs, in an external AC magnetic field (amplitude, 100-500 Oe and frequency 50 kHz -1MHz), has been explored by many researchers, both in vitro and in vivo, as an alternative viable option to treat cancer. The heat energy generated by Néel and Brownian relaxation processes of the internal magnetic spins could be used to elevate local tissue temperature to about 46 ˚C to arrest cancerous growth. …