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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Use Of Text Data In Identifying And Prioritizing Potential Drug Repositioning Candidates, Majid Rastegar-Mojarad
Use Of Text Data In Identifying And Prioritizing Potential Drug Repositioning Candidates, Majid Rastegar-Mojarad
Theses and Dissertations
New drug development costs between 500 million and 2 billion dollars and takes 10-15 years, with a success rate of less than 10%. Drug repurposing (defined as discovering new indications for existing drugs) could play a significant role in drug development, especially considering the declining success rates of developing novel drugs. In the period 2007-2009, drug repurposing led to the launching of 30-40% of new drugs. Typically, new indications for existing medications are identified by accident. However, new technologies and a large number of available resources enable the development of systematic approaches to identify and validate drug-repurposing candidates with significantly …
An Instruction Embedding Model For Binary Code Analysis, Kimberly Michelle Redmond
An Instruction Embedding Model For Binary Code Analysis, Kimberly Michelle Redmond
Theses and Dissertations
Binary code analysis is important for understanding programs without access to the original source code, which is common with proprietary software. Analyzing binaries can be challenging given their high variability: due to growth in tech manufactur- ers, source code is now frequently compiled for multiple instruction set architectures (ISAs); however, there is no formal dictionary that translates between their assem- bly languages. The difficulty of analysis is further compounded by different compiler optimizations and obfuscated malware signatures. Such minutiae means that some vulnerabilities may only be detectable on a fine-grained level. Recent strides in ma- chine learning—particularly in Natural Language …
Indirect Relatedness, Evaluation, And Visualization For Literature Based Discovery, Sam Henry
Indirect Relatedness, Evaluation, And Visualization For Literature Based Discovery, Sam Henry
Theses and Dissertations
The exponential growth of scientific literature is creating an increased need for systems to process and assimilate knowledge contained within text. Literature Based Discovery (LBD) is a well established field that seeks to synthesize new knowledge from existing literature, but it has remained primarily in the theoretical realm rather than in real-world application. This lack of real-world adoption is due in part to the difficulty of LBD, but also due to several solvable problems present in LBD today. Of these problems, the ones in most critical need of improvement are: (1) the over-generation of knowledge by LBD systems, (2) a …
Assessing The Quality Of Software Development Tutorials Available On The Web, Manziba A. Nishi
Assessing The Quality Of Software Development Tutorials Available On The Web, Manziba A. Nishi
Theses and Dissertations
Both expert and novice software developers frequently access software development resources available on the Web in order to lookup or learn new APIs, tools and techniques. Software quality is affected negatively when developers fail to find high-quality information relevant to their problem. While there is a substantial amount of freely available resources that can be accessed online, some of the available resources contain information that suffers from error proneness, copyright infringement, security concerns, and incompatible versions. Use of such toxic information can have a strong negative effect on developer’s efficacy. This dissertation focuses specifically on software tutorials, aiming to automatically …
Curtus: An Nlp Tool To Map Job Skills To Academic Courses, Daniel Rockwell
Curtus: An Nlp Tool To Map Job Skills To Academic Courses, Daniel Rockwell
Theses and Dissertations
Many businesses are burdened with the need to train students for the job instead of finding them prepared for it. Few business leaders feel that colleges prepare students for future jobs from day one. It can be a challenge for colleges to determine if their curricula meet the industry needs. Mapping industry needs to academic courses can be advantageous to both parties as it will allow colleges to be aligned with the industry needs and accordingly satisfy those needs and will allow the industry to hire better prepared graduates. In an attempt to address this, a system prototype that uses …