Physical Sciences and Mathematics Commons^™

A Computational Model For Recovery From Traumatic Brain Injury, Wayne Wakeland, Erin S. Kenzie

Systems Science Faculty Publications and Presentations

A computational simulation model calculates estimated recovery trajectories following traumatic brain injury (TBI). Prior publications include a multi-scale conceptual framework for studying concussion, a systems-level causal loop diagram (CLD) and an analysis of key feedback processes. A set of first order ordinary differential equations and their associated parameters determines recovery trajectories. The model contains 15 state variables, 73 auxiliary variables, and 50 parameters describing TBI pathology in an aggregate fashion at the cellular, network, cognitive and social levels. There are 1200 feedback loops, which give rise to a variety of behavior modes, many of which are highly nonlinear. Exogenous parameters …