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Full-Text Articles in Physical Sciences and Mathematics
Novel Natural Language Processing Models For Medical Terms And Symptoms Detection In Twitter, Farahnaz Golrooy Motlagh
Novel Natural Language Processing Models For Medical Terms And Symptoms Detection In Twitter, Farahnaz Golrooy Motlagh
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This dissertation focuses on disambiguation of language use on Twitter about drug use, consumption types of drugs, drug legalization, ontology-enhanced approaches, and prediction analysis of data-driven by developing novel NLP models. Three technical aims comprise this work: (a) leveraging pattern recognition techniques to improve the quality and quantity of crawled Twitter posts related to drug abuse; (b) using an expert-curated, domain-specific DsOn ontology model that improve knowledge extraction in the form of drug-to-symptom and drug-to-side effect relations; and (c) modeling the prediction of public perception of the drug’s legalization and the sentiment analysis of drug consumption on Twitter. We collected …
Improving Remote Homology Detection Using A Sequence Property Approach, Gina Marie Cooper
Improving Remote Homology Detection Using A Sequence Property Approach, Gina Marie Cooper
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Understanding the structure and function of proteins is a key part of understanding biological systems. Although proteins are complex biological macromolecules, they are made up of only 20 basic building blocks known as amino acids. The makeup of a protein can be described as a sequence of amino acids. One of the most important tools in modern bioinformatics is the ability to search for biological sequences (such as protein sequences) that are similar to a given query sequence. There are many tools for doing this (Altschul et al., 1990, Hobohm and Sander, 1995, Thomson et al., 1994, Karplus and Barrett, …
Algorithmic Techniques Employed In The Isolation Of Codon Usage Biases In Prokaryotic Genomes, Douglas W. Raiford Iii
Algorithmic Techniques Employed In The Isolation Of Codon Usage Biases In Prokaryotic Genomes, Douglas W. Raiford Iii
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While genomic sequencing projects are an abundant source of information for biological studies ranging from the molecular to the ecological in scale, much of the information present may yet be hidden from casual analysis. One such information domain, trends in codon usage, can provide a wealth of information about an organism's genes and their expression. Degeneracy in the genetic code allows more than one triplet codon to code for the same amino acid, and usage of these codons is often biased such that one or more of these synonymous codons is preferred. Isolation of translational efficiency bias can have important …
Computational Methods For The Objective Review Of Forensic Dna Testing Results, Jason R. Gilder
Computational Methods For The Objective Review Of Forensic Dna Testing Results, Jason R. Gilder
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Since the advent of criminal investigations, investigators have sought a "gold standard" for the evaluation of forensic evidence. Currently, deoxyribonucleic acid (DNA) technology is the most reliable method of identification. Short Tandem Repeat (STR) DNA genotyping has the potential for impressive match statistics, but the methodology not infallible. The condition of an evidentiary sample and potential issues with the handling and testing of a sample can lead to significant issues with the interpretation of DNA testing results. Forensic DNA interpretation standards are determined by laboratory validation studies that often involve small sample sizes. This dissertation presents novel methodologies to address …