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Articles 1 - 4 of 4
Full-Text Articles in Physical Sciences and Mathematics
A Computational Framework For Analyzing Chemical Modification And Limited Proteolysis Experimental Data Used For High Confidence Protein Structure Prediction, Paul E. Anderson
A Computational Framework For Analyzing Chemical Modification And Limited Proteolysis Experimental Data Used For High Confidence Protein Structure Prediction, Paul E. Anderson
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Prediction of protein tertiary structure based on amino acid sequence is one of the most challenging open questions in computational molecular biology. Experimental methods for protein structure determination remain relatively time consuming and expensive, and are not applicable to all proteins. While a diverse array of algorithms have been developed for prediction of protein structure from amino acid sequence information, the accuracy and reliability of these methods are not yet comparable to experimental structure determination techniques. Computational models of protein structure can, however, be improved by the incorporation of experimental information. Relatively rapid and inexpensive protein modification experiments can be …
Specification For Visual Requirements Of Work-Centered Software Systems, James Robert Knapp
Specification For Visual Requirements Of Work-Centered Software Systems, James Robert Knapp
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Work-centered software systems function as inherent work-aiding systems. Based on the design concept for a work-centered support system (WCSS), these software systems support user tasks and goals through both direct and indirect aiding methods within the interface client. In order to ensure the coherent development and delivery of work-centered software products, WCSS visual interface requirements must be specified in order to capture the cognitive and work-aiding aspects of the user interface design. Without the ability to specify such original requirements, the probability of creating an accurate and effective work-centered software system is significantly reduced. A new visual requirements specification language …
Investigating The Male-Driven Evolution Hypothesis Using Human AluRepeat Elements, Sridhar Ramachandran
Investigating The Male-Driven Evolution Hypothesis Using Human AluRepeat Elements, Sridhar Ramachandran
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Thousands of copies of short interspersed repeats (SINEs) are scattered essentially ran-domly through the human genome. Although copies of each repeat subfamily are identical at the time of their insertion, they become subject to individual substitutions after insertion. As the relative time of insertion is known for many of these repeats, such "junk DNA" can be used to provide a sizeable number of time-series data points for studying substitution effects in a variety of genomic contexts. This dissertation specifically discusses the usefulness of the Alufamily of SINE repeats towards addressing open problems in genomics, population genetics, and biology in …
A Field Programmable Gate Array Architecture For Two-Dimensional Partial Reconfiguration, Fei Wang
A Field Programmable Gate Array Architecture For Two-Dimensional Partial Reconfiguration, Fei Wang
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Reconfigurable machines can accelerate many applications by adapting to their needs through hardware reconfiguration. Partial reconfiguration allows the reconfiguration of a portion of a chip while the rest of the chip is busy working on tasks. Operating system models have been proposed for partially reconfigurable machines to handle the scheduling and placement of tasks. They are called OS4RC in this dissertation. The main goal of this research is to address some problems that come from the gap between OS4RC and existing chip architectures and the gap between OS4RC models and practical applications. Some existing OS4RC models are based on an …