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Full-Text Articles in Physical Sciences and Mathematics
A Genetic Optimization Approach For Isolating Translational Efficiency Bias, Douglas W. Raiford, Dan E. Krane, Travis E. Doom, Michael L. Raymer
A Genetic Optimization Approach For Isolating Translational Efficiency Bias, Douglas W. Raiford, Dan E. Krane, Travis E. Doom, Michael L. Raymer
Kno.e.sis Publications
The study of codon usage bias is an important research area that contributes to our understanding of molecular evolution, phylogenetic relationships, respiratory lifestyle, and other characteristics. Translational efficiency bias is perhaps the most well studied codon usage bias, as it is frequently utilized to predict relative protein expression levels. We present a novel approach to isolating translational efficiency bias in microbial genomes. There are several existent methods for isolating translational efficiency bias. Previous approaches are susceptible to the confounding influences of other potentially dominant biases. Additionally, existing approaches to identifying translational efficiency bias generally require both genomic sequence information and …
Automated Isolation Of Translational Efficiency Bias That Resists The Confounding Effect Of Gc(At)-Content, Douglas W. Raiford, Dan E. Krane, Travis E. Doom, Michael L. Raymer
Automated Isolation Of Translational Efficiency Bias That Resists The Confounding Effect Of Gc(At)-Content, Douglas W. Raiford, Dan E. Krane, Travis E. Doom, Michael L. Raymer
Kno.e.sis Publications
Genomic sequencing projects are an abundant source of information for biological studies ranging from the molecular to the ecological in scale; however, much of the information present may yet be hidden from casual analysis. One such information domain, trends in codon usage, can provide a wealth of information about an organism's genes and their expression. Degeneracy in the genetic code allows more than one triplet codon to code for the same amino acid, and usage of these codons is often biased such that one or more of these synonymous codons is preferred. Detection of this bias is an important tool …