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Elf3 Is An Antagonist Of Oncogenic-Signalling-Induced Expression Of Emt-Tf Zeb1, D Liu, Y Skomorovska, J Song, E Bowler, R Harris, R Ravasz, S Bai, Marzieh Ayati, K Tamai, Mehmet Koyuturk
Elf3 Is An Antagonist Of Oncogenic-Signalling-Induced Expression Of Emt-Tf Zeb1, D Liu, Y Skomorovska, J Song, E Bowler, R Harris, R Ravasz, S Bai, Marzieh Ayati, K Tamai, Mehmet Koyuturk
Computer Science Faculty Publications and Presentations
Background: Epithelial-to-mesenchymal transition (EMT) is a key step in the transformation of epithelial cells into migratory and invasive tumour cells. Intricate positive and negative regulatory processes regulate EMT. Many oncogenic signalling pathways can induce EMT, but the specific mechanisms of how this occurs, and how this process is controlled are not fully understood.
Methods: RNA-Seq analysis, computational analysis of protein networks and large-scale cancer genomics datasets were used to identify ELF3 as a negative regulator of the expression of EMT markers. Western blotting coupled to siRNA as well as analysis of tumour/normal colorectal cancer panels was used to …