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Full-Text Articles in Physical Sciences and Mathematics
A Trend Pattern Assessment Approach To Microarray Gene Expression Profiling Data Analysis, Kahai Cao, Qiuming Zhu, Javeed Iqbal, John W.C. Chan
A Trend Pattern Assessment Approach To Microarray Gene Expression Profiling Data Analysis, Kahai Cao, Qiuming Zhu, Javeed Iqbal, John W.C. Chan
Computer Science Faculty Publications
We study the problem of how to assess the reliability of a statistical measurement on data set containing unknown quantity of noises, inconsistencies, and outliers. A practical approach that analyzes the dynamical patterns (trends) of the statistical measurements through a sequential extreme-boundary-points (EBP) weed-out process is explored. We categorize the weed-out trend patterns (WOTP) and examine their relation to the reliability of the measurement. The approach is applied to the processes of extracting genes that are predictive to BCL2 translocations and to clinical survival outcomes of diffuse large B-cell lymphoma (DLBCL) from DNA Microarray gene expression profiling data sets. Fisher’s …