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Articles 1 - 7 of 7
Full-Text Articles in Physical Sciences and Mathematics
A Transfer Learning Approach For Sentiment Classification., Omar Abdelwahab
A Transfer Learning Approach For Sentiment Classification., Omar Abdelwahab
Electronic Theses and Dissertations
The idea of developing machine learning systems or Artificial Intelligence agents that would learn from different tasks and be able to accumulate that knowledge with time so that it functions successfully on a new task that it has not seen before is an idea and a research area that is still being explored. In this work, we will lay out an algorithm that allows a machine learning system or an AI agent to learn from k different domains then uses some or no data from the new task for the system to perform strongly on that new task. In order …
Bayesian Analytical Approaches For Metabolomics : A Novel Method For Molecular Structure-Informed Metabolite Interaction Modeling, A Novel Diagnostic Model For Differentiating Myocardial Infarction Type, And Approaches For Compound Identification Given Mass Spectrometry Data., Patrick J. Trainor
Electronic Theses and Dissertations
Metabolomics, the study of small molecules in biological systems, has enjoyed great success in enabling researchers to examine disease-associated metabolic dysregulation and has been utilized for the discovery biomarkers of disease and phenotypic states. In spite of recent technological advances in the analytical platforms utilized in metabolomics and the proliferation of tools for the analysis of metabolomics data, significant challenges in metabolomics data analyses remain. In this dissertation, we present three of these challenges and Bayesian methodological solutions for each. In the first part we develop a new methodology to serve a basis for making higher order inferences in metabolomics, …
Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller
Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller
Electronic Theses and Dissertations
The inherent heterogeneity of tumor tissue presents a major challenge to nanoparticle-medicated drug delivery. This heterogeneity spans from the molecular to the cellular (cell types) and to the tissue (vasculature, extra-cellular matrix) scales. Here we employ computational modeling to evaluate therapeutic response as a function of vascular-induced tumor tissue heterogeneity. Using data with three-layered gold nanoparticles loaded with cisplatin, nanotherapy is simulated with different levels of tissue heterogeneity, and the treatment response is measured in terms of tumor regression. The results show that tumor vascular density non-trivially influences the nanoparticle uptake and washout, and the associated tissue response. The drug …
Designing Interactive Virtual Environments With Feedback In Health Applications., Yi Li
Designing Interactive Virtual Environments With Feedback In Health Applications., Yi Li
Electronic Theses and Dissertations
One of the most important factors to influence user experience in human-computer interaction is the user emotional reaction. Interactive environments including serious games that are responsive to user emotions improve their effectiveness and user satisfactions. Testing and training for user emotional competence is meaningful in healthcare field, which has motivated us to analyze immersive affective games using emotional feedbacks. In this dissertation, a systematic model of designing interactive environment is presented, which consists of three essential modules: affect modeling, affect recognition, and affect control. In order to collect data for analysis and construct these modules, a series of experiments were …
Region Based Gene Expression Via Reanalysis Of Publicly Available Microarray Data Sets., Ernur Saka
Region Based Gene Expression Via Reanalysis Of Publicly Available Microarray Data Sets., Ernur Saka
Electronic Theses and Dissertations
A DNA microarray is a high-throughput technology used to identify relative gene expression. One of the most widely used platforms is the Affymetrix® GeneChip® technology which detects gene expression levels based on probe sets composed of a set of twenty-five nucleotide probes designed to hybridize with specific gene targets. Given a particular Affymetrix® GeneChip® platform, the design of the probes is fixed. However, the method of analysis is dynamic in nature due to the ability to annotate and group probes into uniquely defined groupings. This is particularly important since publicly available repositories of microarray datasets, such as ArrayExpress and NCBI’s …
Network Science Algorithms For Mobile Networks., Heba Mohamed Elgazzar
Network Science Algorithms For Mobile Networks., Heba Mohamed Elgazzar
Electronic Theses and Dissertations
Network Science is one of the important and emerging fields in computer science and engineering that focuses on the study and analysis of different types of networks. The goal of this dissertation is to design and develop network science algorithms that can be used to study and analyze mobile networks. This can provide essential information and knowledge that can help mobile networks service providers to enhance the quality of the mobile services. We focus in this dissertation on the design and analysis of different network science techniques that can be used to analyze the dynamics of mobile networks. These techniques …
Multi Self-Adapting Particle Swarm Optimization Algorithm (Msapso)., Gerhard Koch
Multi Self-Adapting Particle Swarm Optimization Algorithm (Msapso)., Gerhard Koch
Electronic Theses and Dissertations
The performance and stability of the Particle Swarm Optimization algorithm depends on parameters that are typically tuned manually or adapted based on knowledge from empirical parameter studies. Such parameter selection is ineffectual when faced with a broad range of problem types, which often hinders the adoption of PSO to real world problems. This dissertation develops a dynamic self-optimization approach for the respective parameters (inertia weight, social and cognition). The effects of self-adaption for the optimal balance between superior performance (convergence) and the robustness (divergence) of the algorithm with regard to both simple and complex benchmark functions is investigated. This work …