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Full-Text Articles in Physical Sciences and Mathematics

Designing And Sample Size Calculation In Presence Of Heterogeneity In Biological Studies Involving High-Throughput Data., Sudhir Srivastava Aug 2019

Designing And Sample Size Calculation In Presence Of Heterogeneity In Biological Studies Involving High-Throughput Data., Sudhir Srivastava

Electronic Theses and Dissertations

The designing and determination of sample size are important for conducting high-throughput biological experiments such as proteomics experiments and RNA-Seq expression studies, thus leading to better understanding of complex mechanisms underlying various biological processes. The variations in the biological data or technical approaches to data collection lead to heterogeneity for the samples under study. We critically worked on the issues of technical and biological heterogeneity. The quantitative measurements based on liquid chromatography (LC) coupled with mass spectrometry (MS) often suffer from the problem of missing values (MVs) and data heterogeneity. We considered a proteomics data set generated from human kidney …


Formally Designing And Implementing Cyber Security Mechanisms In Industrial Control Networks., Mehdi Sabraoui Aug 2019

Formally Designing And Implementing Cyber Security Mechanisms In Industrial Control Networks., Mehdi Sabraoui

Electronic Theses and Dissertations

This dissertation describes progress in the state-of-the-art for developing and deploying formally verified cyber security devices in industrial control networks. It begins by detailing the unique struggles that are faced in industrial control networks and why concepts and technologies developed for securing traditional networks might not be appropriate. It uses these unique struggles and examples of contemporary cyber-attacks targeting control systems to argue that progress in securing control systems is best met with formal verification of systems, their specifications, and their security properties. This dissertation then presents a development process and identifies two technologies, TLA+ and seL4, that can be …


Clustering Of Multiple Instance Data., Andrew D. Karem May 2019

Clustering Of Multiple Instance Data., Andrew D. Karem

Electronic Theses and Dissertations

An emergent area of research in machine learning that aims to develop tools to analyze data where objects have multiple representations is Multiple Instance Learning (MIL). In MIL, each object is represented by a bag that includes a collection of feature vectors called instances. A bag is positive if it contains at least one positive instance, and negative if no instances are positive. One of the main objectives in MIL is to identify a region in the instance feature space with high correlation to instances from positive bags and low correlation to instances from negative bags -- this region is …


An Explainable Sequence-Based Deep Learning Predictor With Applications To Song Recommendation And Text Classification., Khalil Damak May 2019

An Explainable Sequence-Based Deep Learning Predictor With Applications To Song Recommendation And Text Classification., Khalil Damak

Electronic Theses and Dissertations

Streaming applications are now the predominant tools for listening to music. What makes the success of such software is the availability of songs and especially their ability to provide users with relevant personalized recommendations. State of the art music recommender systems mainly rely on either Matrix factorization-based collaborative filtering approaches or deep learning architectures. Deep learning models usually use metadata for content-based filtering or predict the next user interaction (listening to a song) using a memory-based deep learning structure that learns from temporal sequences of user actions. Despite advances in deep learning models for song recommendation systems, none has taken …


Studying And Handling Iterated Algorithmic Biases In Human And Machine Learning Interaction., Wenlong Sun May 2019

Studying And Handling Iterated Algorithmic Biases In Human And Machine Learning Interaction., Wenlong Sun

Electronic Theses and Dissertations

Algorithmic bias consists of biased predictions born from ingesting unchecked information, such as biased samples and biased labels. Furthermore, the interaction between people and algorithms can exacerbate bias such that neither the human nor the algorithms receive unbiased data. Thus, algorithmic bias can be introduced not only before and after the machine learning process but sometimes also in the middle of the learning process. With a handful of exceptions, only a few categories of bias have been studied in Machine Learning, and there are few, if any, studies of the impact of bias on both human behavior and algorithm performance. …