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Full-Text Articles in Physical Sciences and Mathematics
A New Essential Protein Discovery Method Based On The Integration Of Protein-Protein Interaction And Gene Expression Data, Min Li, Hanhui Zhang, Jian-Xin Wang, Yi Pan
A New Essential Protein Discovery Method Based On The Integration Of Protein-Protein Interaction And Gene Expression Data, Min Li, Hanhui Zhang, Jian-Xin Wang, Yi Pan
Computer Science Faculty Publications
The article offers information on a study conducted on the essential protein discovery method, PeC, which is based on the integration of protein-protein interaction and gene expression data. It states that PeC was developed on the basis of the definitions of edge clustering coefficient (ECC) and Pearson's correlation coefficient (PCC). It mentions that a list of essential proteins of Saccharomyces cerevisiae were collected.
Background: Identification of essential proteins is always a challenging task since it requires experimental approaches that are time-consuming and laborious. With the advances in high throughput technologies, a large number of protein-protein interactions are available, which have …
Iteration Method For Predicting Essential Proteins Based On Orthology And Protein-Protein Interaction Networks, Wei Peng, Jianxin Wang, Weiping Wang, Qing Liu, Fang-Xiang Wu, Yi Pan
Iteration Method For Predicting Essential Proteins Based On Orthology And Protein-Protein Interaction Networks, Wei Peng, Jianxin Wang, Weiping Wang, Qing Liu, Fang-Xiang Wu, Yi Pan
Computer Science Faculty Publications
Background: Identification of essential proteins plays a significant role in understanding minimal requirements for the cellular survival and development. Many computational methods have been proposed for predicting essential proteins by using the topological features of protein-protein interaction (PPI) networks. However, most of these methods ignored intrinsic biological meaning of proteins. Moreover, PPI data contains many false positives and false negatives. To overcome these limitations, recently many research groups have started to focus on identification of essential proteins by integrating PPI networks with other biological information. However, none of their methods has widely been acknowledged.
Results: By considering the facts that …