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Full-Text Articles in Physical Sciences and Mathematics
Informative Snp Selection And Validation, Diana Mohan Babu
Informative Snp Selection And Validation, Diana Mohan Babu
Computer Science Theses
The search for genetic regions associated with complex diseases, such as cancer or Alzheimer's disease, is an important challenge that may lead to better diagnosis and treatment. The existence of millions of DNA variations, primarily single nucleotide polymorphisms (SNPs), may allow the fine dissection of such associations. However, studies seeking disease association are limited by the cost of genotyping SNPs. Therefore, it is essential to find a small subset of informative SNPs (tag SNPs) that may be used as good representatives of the rest of the SNPs. Several informative SNP selection methods have been developed. Our experiments compare favorably to …
A Domain-Specific Conceptual Query System, Xiuyun Shen
A Domain-Specific Conceptual Query System, Xiuyun Shen
Computer Science Theses
This thesis presents the architecture and implementation of a query system resulted from a domain-specific conceptual data modeling and querying methodology. The query system is built for a high level conceptual query language that supports dynamically user-defined domain-specific functions and application-specific functions. It is DBMS-independent and can be translated to SQL and OQL through a normal form. Currently, it has been implemented in neuroscience domain and can be applied to any other domain.