Physical Sciences and Mathematics Commons^™

Learn Biologically Meaningful Representation With Transfer Learning, Di He

Dissertations, Theses, and Capstone Projects

Machine learning has made significant contributions to bioinformatics and computational biol­ogy. In particular, supervised learning approaches have been widely used in solving problems such as bio­marker identification, drug response prediction, and so on. However, because of the limited availability of comprehensively labeled and clean data, constructing predictive models in super­ vised settings is not always desirable or possible, especially when using data­hunger, red­hot learning paradigms such as deep learning methods. Hence, there are urgent needs to develop new approaches that could leverage more readily available unlabeled data in driving successful machine learning ap­ plications in this area.

In my dissertation, …

Speech Enhancement Using Speech Synthesis Techniques, Soumi Maiti

Dissertations, Theses, and Capstone Projects

Traditional speech enhancement systems reduce noise by modifying the noisy signal to make it more like a clean signal, which suffers from two problems: under-suppression of noise and over-suppression of speech. These problems create distortions in enhanced speech and hurt the quality of the enhanced signal. We propose to utilize speech synthesis techniques for a higher quality speech enhancement system. Synthesizing clean speech based on the noisy signal could produce outputs that are both noise-free and high quality. We first show that we can replace the noisy speech with its clean resynthesis from a previously recorded clean speech dictionary from …