Physical Sciences and Mathematics Commons^™

Feature Identification And Reduction For Improved Generalization Accuracy In Secondary-Structure Prediction Using Temporal Context Inputs In Machine-Learning Models, Matthew Benjamin Seeley

Theses and Dissertations

A protein's properties are influenced by both its amino-acid sequence and its three-dimensional conformation. Ascertaining a protein's sequence is relatively easy using modern techniques, but determining its conformation requires much more expensive and time-consuming techniques. Consequently, it would be useful to identify a method that can accurately predict a protein's secondary-structure conformation using only the protein's sequence data. This problem is not trivial, however, because identical amino-acid subsequences in different contexts sometimes have disparate secondary structures, while highly dissimilar amino-acid subsequences sometimes have identical secondary structures. We propose (1) to develop a set of metrics that facilitates better comparisons between …