Physical Sciences and Mathematics Commons^™

Using Hidden Markov Models To Detect Dna Motifs, Santrupti Nerli

Master's Projects

During the process of gene expression in eukaryotes, mRNA splicing is one of the key processes carried out by a complex called spliceosome. Spliceosome guarantees proper removal of introns and joining of exons before the translation process. Precise splicing is essential for the production of functional proteins. Spliceosome detects specific sequence motifs within an mRNA sequence called splice sites. Two of the splice sites are the 5’ and 3’ sites that border all the introns. Normal splicing process if disrupted by mutation may lead to fatal diseases. In this work, we predict splice sites in a human genome using hidden …