Physical Sciences and Mathematics Commons^™

Tumor-Targeting Fluorinated Phthalocyanines For Theranostic Applications, Erik Nathaniel Carrión

Seton Hall University Dissertations and Theses (ETDs)

Hydrocarbon-based therapeutics and imaging agents are prone to chemical oxidation and degradation resulting in loss of activity and limited functional utility. Thus, more material is required to achieve long-lasting therapeutic effects. Phthalocyanines (Pcs) and their metal complexes (PcMs) can be utilized as prodrugs requiring only renewable energy resources namely, air and light, for cancer therapy and diagnostic (theranostic) applications related to photodynamic therapy (PDT). Replacement of labile C-H bonds in the Pc scaffold with a combination of fluoro and perfluoroisopropyl groups has resulted in a stable yet reactive oxidation catalyst of biological significance and importance. For example, F₆₄PcZn, …

Fluorinated Metallo Phthalocyanines For Chemical And Biological Catalysis, Hemantbhai H. Patel

Seton Hall University Dissertations and Theses (ETDs)

The rational design of robust oxidation catalysts based on organic molecules is hindered by the presence of labile C-H bonds. We have shown recently that replacing all C-H bonds by a combination of fluoro- and perfluoro-groups in a bioinspired Cytochrome P450 model based on a phthalocyanine, Pc, scaffold results in a stable yet reactive oxidation catalyst. The Pc cobalt complex catalyzes, for example, the aerobic oxidation of thiols to disulfides, a reaction of both biological significance and industrial importance.

The presence of robust C-F bonds, however, renders the catalyst unsuitable for attachment to solid-state supports, except via van der Waals …

New Strategies For The Synthesis Of Porphyrinoids, Moses Inyanje Ihachi

LSU Doctoral Dissertations

ABSTRACT Chapter 1 describes the most stable isomer of porphyrin called porphycene. In this chapter photodynamic therapy (PDT) is explained, and the application of porphycenes in PDT is also described. Other biological applications and its uses in catalysis are also summarized here. The general chemical reactions of porphycenes are also explained. Chapter 2 involves the synthesis of pyrroles and bipyrroles. Functionalization of pyrrollic substituents is demonstrated using organometallic coupling reactions like Stille coupling and Grubbs olefin metathesis. The synthesis of divinyl bipyrroles is intended to provide an important precursor to porphycene synthesis via ring closing metathesis using Grubbs catalyst. Chapter …