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Full-Text Articles in Physical Sciences and Mathematics
Definition Of The Chalcogen Bond (Iupac Recommendations 2019), Christer B. Aakeroy, David L. Bryce, Gautam R. Desiraju, Antonio Frontera, Anthony C. Legon, Francesco Nicotra, Kari Rissanen, Steve Scheiner, Giancarlo Terraneo, Pierangelo Metrangolo, Giuseppe Resnati
Definition Of The Chalcogen Bond (Iupac Recommendations 2019), Christer B. Aakeroy, David L. Bryce, Gautam R. Desiraju, Antonio Frontera, Anthony C. Legon, Francesco Nicotra, Kari Rissanen, Steve Scheiner, Giancarlo Terraneo, Pierangelo Metrangolo, Giuseppe Resnati
Chemistry and Biochemistry Faculty Publications
This recommendation proposes a definition for the term “chalcogen bond”; it is recommended the term is used to designate the specific subset of inter- and intramolecular interactions formed by chalcogen atoms wherein the Group 16 element is the electrophilic site.
Structural And Functional Characterization Of Sulfonium Carbon-Oxygen Hydrogen Bonding In The Deoxyamino Sugar Methyltransferase Tyim1, Robert J. Fick, Scott Horowitz, Brandon G. Mcdole, Mary C. Clay, Ryan A. Mehl, Hashim M. Al-Hashimi, Steve Scheiner, Raymond C. Trievel
Structural And Functional Characterization Of Sulfonium Carbon-Oxygen Hydrogen Bonding In The Deoxyamino Sugar Methyltransferase Tyim1, Robert J. Fick, Scott Horowitz, Brandon G. Mcdole, Mary C. Clay, Ryan A. Mehl, Hashim M. Al-Hashimi, Steve Scheiner, Raymond C. Trievel
Chemistry and Biochemistry Faculty Publications
The N-methyltransferase TylM1 from Streptomyces fradiae catalyzes the final step in the biosynthesis of the deoxyamino sugar mycaminose, a substituent of the antibiotic tylosin. The high-resolution crystal structure of TylM1 bound to the methyl donor S-adenosylmethionine (AdoMet) illustrates a network of carbon-oxygen (CH•••O) hydrogen bonds between the substrate’s sulfonium cation and residues within the active site. These interactions include hydrogen bonds between the methyl and methylene groups of the AdoMet sulfonium cation and the hydroxyl groups of Tyr14 and Ser120 in the enzyme. To examine the functions of these interactions, we generated Tyr14 to phenylalanine (Y14F) and Ser120 to alanine …
Toward Macromolecular Shape And Size Control: Novel Enantioselective Nitrations And Iterative Exponential Growth Methods For Polymer Synthesis, Joseph Patrick Campbell
Toward Macromolecular Shape And Size Control: Novel Enantioselective Nitrations And Iterative Exponential Growth Methods For Polymer Synthesis, Joseph Patrick Campbell
Graduate College Dissertations and Theses
Chirality is a key principle in organic chemistry. All chiral compounds are non-superimposable mirror images of each other and therefore lack an improper axis of rotation (Sn). These mirror images often have identical properties in an achiral environment, however when two chiral molecules interact, they produce different shapes and properties. Nature, to this extent takes advantage of this aspect through unique formation of shape defined biological macromolecules that are tailored to carry out various life processes. This level of shape control is only made possible because of natural chiral monomers such as amino acids or glycosides that make up such …