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Full-Text Articles in Physical Sciences and Mathematics
$N$-Acylazole Mediated Stereoselective And Regioselective Synthesis Of $N$-Substituted Azole Acrylonitriles, Osman Aydin, Şule Kökten, Hakan Ünver, İlhami̇ Çeli̇k
$N$-Acylazole Mediated Stereoselective And Regioselective Synthesis Of $N$-Substituted Azole Acrylonitriles, Osman Aydin, Şule Kökten, Hakan Ünver, İlhami̇ Çeli̇k
Turkish Journal of Chemistry
Regio- and stereoselective synthesis of $N$-substituted azole acrylonitriles has been achieved smoothly in $N,N$-dimethylformamide (DMF) in the presence of potassium carbonate (K$_{2}$CO$_{3})$ as a base catalyst. $N$-Substituted azole acrylonitriles were obtained in moderate to good yields (39%-87%) with a one-pot reaction between readily available $N$-acetylazoles and Baylis-Hillman nitriles. The structural determinations were accomplished by NOESY $^{1}$H NMR and X-ray crystallography.
One-Pot Synthesis Of Quinazolin-4(3$H$)-Ones And 2,3-Dihydroquinazolin-4(1$H$)-Ones Utilizing $N$-(2-Aminobenzoyl)Benzotriazoles, İlbi̇lge Merve Şenol, İlhami̇ Çeli̇k, İlker Avan
One-Pot Synthesis Of Quinazolin-4(3$H$)-Ones And 2,3-Dihydroquinazolin-4(1$H$)-Ones Utilizing $N$-(2-Aminobenzoyl)Benzotriazoles, İlbi̇lge Merve Şenol, İlhami̇ Çeli̇k, İlker Avan
Turkish Journal of Chemistry
A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3$H)$-ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3$H)$-ones, and 2,3-dihydroquinazolin-4(1$H)$-ones were obtained at yields of 46% to 95% by a one-pot reaction of $N$-(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions.