Physical Sciences and Mathematics Commons^™

Adsorption Of Bovine Serum Albumin (Bsa) By Bare Magnetite Nanoparticles With Surface Oxidative Impurities That Prevent Aggregation, Somayeh Rahdar, Abbas Rahdar, Shahin Ahmadi, John F. Trant

Chemistry and Biochemistry Publications

Bare, uncoated magnetite nanoparticles, synthesized using an electrochemical surfactant-free synthesis, have highly oxidized surfaces that prevent aggregation. These particles have demonstrated highly intriguing biological activity showing extremely potent antibiotic activity against both gram-positive and gram-negative bacteria with little toxicity to rats. This difference in activity could be ascribed to the nature of the protein corona. In this study the kinetics and thermodynamics of the binding of bovine serum albumin, used as a model serum protein, to these magnetite nanoparticles was analyzed. There is no significant change in particle diameter by dynamic light scattering following adsorption indicating corona formation does not …