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Full-Text Articles in Physical Sciences and Mathematics
Rigorous Computational And Experimental Investigations On Mdm2/Mdmx-Targeted Linear And Macrocyclic Peptides, David J. Diller, Jon Swanson, Alexander S. Bayden, Chris J. Brown, Dawn Thean, David P. Lane, Anthony W. Patridge, Tomi K. Sawyer, Joseph Audie
Rigorous Computational And Experimental Investigations On Mdm2/Mdmx-Targeted Linear And Macrocyclic Peptides, David J. Diller, Jon Swanson, Alexander S. Bayden, Chris J. Brown, Dawn Thean, David P. Lane, Anthony W. Patridge, Tomi K. Sawyer, Joseph Audie
Chemistry & Physics Faculty Publications
There is interest in peptide drug design, especially for targeting intracellular protein–protein interactions. Therefore, the experimental validation of a computational platform for enabling peptide drug design is of interest. Here, we describe our peptide drug design platform (CMDInventus) and demonstrate its use in modeling and predicting the structural and binding aspects of diverse peptides that interact with oncology targets MDM2/MDMX in comparison to both retrospective (pre-prediction) and prospective (post-prediction) data. In the retrospective study, CMDInventus modules (CMDpeptide, CMDboltzmann, CMDescore and CMDyscore) were used to accurately reproduce structural and binding data across multiple MDM2/MDMX data sets. In the prospective study, CMDescore, …
Electrochemical Amperometric Biosensor Applications Of Nanostructured Metal Oxides: A Review, Bünyamin Sahin, Tolga Kaya
Electrochemical Amperometric Biosensor Applications Of Nanostructured Metal Oxides: A Review, Bünyamin Sahin, Tolga Kaya
School of Computer Science & Engineering Faculty Publications
Biological sensors have been extensively investigated during the last few decades. Among the diverse facets of biosensing research, nanostructured metal oxides (NMOs) offer a plethora of potential benefits. In this article, we provide a thorough review on the sensor applications of NMOs such as glucose, cholesterol, urea, and uric acid. A detailed analysis of the literature is presented with organized tables elaborating the fundamental characteristics of sensors including the sensitivity, limit of detection, detection range, and stability parameters such as duration, relative standard deviation, and retention. Further analysis was provided through an innovative way of displaying the sensitivity and linear …