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Full-Text Articles in Physical Sciences and Mathematics

Coupling Scanning Electrochemical Microscopy And 3d Modelling To Probe Membrane Permeability Of Human Bladder Cancer (T24) Cells, Fraser Filice Sep 2018

Coupling Scanning Electrochemical Microscopy And 3d Modelling To Probe Membrane Permeability Of Human Bladder Cancer (T24) Cells, Fraser Filice

Electronic Thesis and Dissertation Repository

Scanning electrochemical microscopy (SECM) scans a biased ultramicroelectrode (≤ 25 µm) probe over a sample to characterize topography, physical properties and chemical reactivity. In this dissertation, SECM was used to investigate the metal-induced changes in membrane response of single live human bladder cancer cells (T24). SECM imaging was coupled to 3D finite element method (FEM) simulations which were the first of their kind, providing advanced quantification of sample traits under conditions not previously usable.

The effects of Cd2+ on T24 cell membrane permeability were examined. Experimental depth-scan imaging was coupled with full 3D FEM simulations, eliminating many limitations of …


Key Enzymes In Cancer: Mechanism Of Action And Inhibition With Anticancer Agents, Debasish Bandyopadhyay, Gabriel Lopez, Stephanie Cantu, Samantha Balboa, Annabel Garcia, Christina Silva, Diandra Valdes Jan 2018

Key Enzymes In Cancer: Mechanism Of Action And Inhibition With Anticancer Agents, Debasish Bandyopadhyay, Gabriel Lopez, Stephanie Cantu, Samantha Balboa, Annabel Garcia, Christina Silva, Diandra Valdes

Chemistry Faculty Publications and Presentations

Several enzymes play significant role in different stages of cancer including proliferation, invasion, metastasis and angiogenesis. Mechanism of actions of a few key enzymes along with their inhibitors have been discussed with particular attentation to riboneucleotide reductase, thymidylate synthease, topoisomerase II, interleukins, cell survival proteins and aminopeptidase N.