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Full-Text Articles in Physical Sciences and Mathematics
The Reactivity Of Potassium Carbanions With Epoxides, Christina Dorado
The Reactivity Of Potassium Carbanions With Epoxides, Christina Dorado
Open Access Theses & Dissertations
The reaction of &alpha-cumylpotassium and cyclohexene oxide produces trans-cumylcyclohexanol in high yield in the presence of excess cumene. Reactions of 1.1 and 2.0 equivalents of cumene with one equivalent of n-butylpotassium to make &alpha-cumylpotassium were shown to take several days to reach a maximum yield in the subsequent reaction of &alpha-cumylpotassium and cyclohexene oxide. Although it was initially hypothesized that the high yield was attributed to the interaction of the potassium with the aromatic rings of the &alpha-cumyl anion and the excess cumene, which was confirmed by molecular modeling studies, these reactions demonstrated that no large excess of …
Chromium Salen, Gráinne Hargaden, Pier Giorgio Cozzi
Antimicrobial Activity Of Eugenol Derivatives, George Eyambe, Luis Canales, Bimal K. Banik
Antimicrobial Activity Of Eugenol Derivatives, George Eyambe, Luis Canales, Bimal K. Banik
Chemistry Faculty Publications and Presentations
The antibacterial properties of the clove plant are due to the presence of eugenol, an aromatic phenolic compound. Eugenol was isolated from clove by stem distillation. The alkene group in eugenol was epoxidized resulting in the synthesis of epoxide-eugenol. The heterocyclic ring in epoxide was cleaved to a bromoalcohol derivative. The compounds synthesized epoxideeugenol, bromo alcohol and euginol were tested for antimicrobial activity against Staphylococcus aureus (ATCC 25923). Epoxide-eugenol was found to be the most effective antimicrobial agent among the three compounds tested.