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Full-Text Articles in Physical Sciences and Mathematics
Nmr Study Of Neurophysin Dimer Dissociation By Cosolvents, Jian Yao
Nmr Study Of Neurophysin Dimer Dissociation By Cosolvents, Jian Yao
Dissertations and Theses
Neurophysins (NPs) make up a relatively small, stable, and highly soluble class of proteins. They have physiological roles of storage and stabilizing' of peptide hormones oxytocin and vasopression within the posterior pituitary neurosecretory granules. At the concentration of NP found within the granules, NP would exist as a dimer in the absence or presence of bound peptide. The NP monomer-monomer interface involves B-sheet/ B-sheet contact, which can be modulated by the presence of cosolvent. This remarkable feature of NP makes it a model for Alzheimer's disease. One of the characteristics of Alzheimer's disease is the presence of plaques of B-amyloid …
A New High Pressure Sapphire Nuclear Magnetic Resonance Cell, Shi Bai, Craig M. Taylor, Charles L. Mayne, Ronald J. Pugmire, David M. Grant
A New High Pressure Sapphire Nuclear Magnetic Resonance Cell, Shi Bai, Craig M. Taylor, Charles L. Mayne, Ronald J. Pugmire, David M. Grant
Faculty Publications
A new version of a single-crystal sapphire high pressure nuclear magnetic resonance (NMR) cell is described that is capable of controlling the sample pressure independent of the temperature. A movable piston inside the cell adjusts and controls the sample pressure from ambient conditions to 200 atm within plus or minus 0.3 atm. The linewidth at half-height for a 13C spectrum of carbon dioxide at 15degrees C and 57.8 atm is found to be 0.5 Hz. The carbon dioxide gas/liquid phase transition is clearly observed by measuring 13C chemical shifts as the sample pressure approaches equilibrium. The time required for this …