Physical Sciences and Mathematics Commons^™

Preparation Of Compounds Of Potential Physiological Activity: Amino And Thio Esters Of Substituted Benzilic And Glycolic Acids And Related Compounds, Dan Millard Glenn

Doctoral Dissertations

Interest in medicinal chemistry has been high during the last two decades all over the world, and particularly in the United States. It has been stimulated by improved methods of clinical diagnosis and the ensuing demands for new corrective and curative agents, by the need for better medicinals in the treatment of the growing number of aged individuals, by the urgency of wartime search for anti-infectious drugs, by the greater significance of pharmaceutical theories, and by the unpredicated expansion of the American pharmaceutical industry. The proof of the structure of most vitamins and of many internally secreted products and the …

An Investigation Of The Reduction Of Carbon-Carbon Unsaturation By Alkali Metals In Liquid Ammonia, Donald Richard Larkin

Doctoral Dissertations

Introduction: The properties of liquid ammonia are similar in many ways to those of water. Liquid ammonia has the very high specific heat of 1.10 calories per gram. Hydrogen bonding occurs to a considerable degree although not as extensively as in water. Evidence of hydrogen bonding as reflected in boiling points is shown in Table I. The dielectric constant is 22 at -33° which is also very high for a solvent which is comparatively inert to reactive metals. (Hexane has a dielectric constant of 1.87.) Liquid ammonia is a much better solvent for organic compounds than water. Even such large …

Preparation Of Compounds Of Potential Physiological Activity: Derivatives Of Benzilic, Substituted Acetic And Substituted Glycolic Acids And Substituted Butanones, Thomas Alexander Magee

Doctoral Dissertations

The continuing search of chemists, physiologists and medical researchers for natural and synthetic compounds which will alleviate or cure the illnesses of mankind constitutes a fascinating episode in the history of scientific endeavor. One chapter of this history is necessarily concerned with efforts to synthesize better, more useful antispasmodics. To present a comprehensive critical review of these efforts would require an extensive treatise and will not be attempted here. Several reviews are available which cover the literature to around 1950. The present survey will be a brief resume of the more pertinent material to the present time. It is hoped …

An Investigation Of Techniques For The Separation Of Hydrogen And Deuterium: Part I: Zone Refining Of Mixtures Of Ordinary And Heavy Water; Part Ii: The Reaction Of Iron With Mixtures Of Ordinary And Heavy Water; Part Iii: Gas Chromatography With Hydrogen And Deuterium Samples, Carl Owens Thomas

Doctoral Dissertations

The separation factor for a single fractional crystallization in the H₂O-D₂O system is much too small, and the required freezing rate is too slow for a batch process to give a useful separation of the isotopic forms of water. The purpose of this work was to continue some preliminary experiments on zone refining in the H₂O-D₂O system and to attempt to determine whether or not the technique would be useful for the separation of heavy water from ordinary water.

Adsorption Studies Of Organic Compounds On The Hydrogen Electrode Using A Microcoulometric Technique, Philip Lamar Oglesby

Master's Theses

This work was concerned with the adsorption of various organic compounds and their effect on the hydrogen electrode where adsorption is defined as the accumulation of a chemical substance at the boundary separating two phases. In this case, the two phases were the electrode and the ionic solution surrounding it.

The Synthesis Of Some Methyl Substituted 3,4-Benzpyrenes, Jules L. Adelfang

Chemistry and Chemical Biology ETDs

3,4-Benzpyrene (I), a highly carcinogenic hydrocarbon was first isolated from coal tar in 1933 by Cook, Hewett, and Hieger. Interest in the relationship of structure to carcinogenic activity and correlation of physical properties with carcinogenic potency led to the synthesis of several monomethyl 3,4-benzpyrenes during the decade following the isolation of the parent hydrocarbon. Detailed reviews concerned with the various phases of this research have been prepared. Recently the synthesis of the 1-^2, 7-^3, 8-^(2,5), and 10-^4 methyl-3,4-benzpyrenes completed the series of reported monomethyl derivaives.

Rhenium Catalysis I. Hydrogenation And Hydroformylation Using Rhenium Carbonyl Compounds ; Ii. Hydrogenation Using Catalysts Obtained From The Reduction Of Perrhenates With Metals In Aqueous Solution, Terry G. Selin

Theses and Dissertations

The purpose of this work was to investigate the catalytic activity in both hydrogenation and hydroformylation reactions of rhenium preparations which have not been previously characterized. Rhenium pentacarbonyl was prepared in good yield from rhenium heptoxide and carbon monoxide. The optimum conditions for preparation were 25 hours per gram of dry rhenium heptoxide at 250° under 3000 psig. (initial) of carbon monoxide. Rhenium chloropentacarbonyl was prepared in 62% yield from potassium chlororhenite and carbon monoxide at high temperatures and pressures. The iodopentacarbonyl was prepared in 29% yield from potassium perrhenate, methyl iodide, and carbon monoxide. The preparation of rhenium hydrocarbonyl …

The Preparation And Catalytic Properties Of Rhenium Blacks Obtained By Reduction Of Re(Vii) In Anhydrous Ammonia And Amines With Alkali Metals, David William Seegmiller

Theses and Dissertations

The purpose of the investigation was to determine the catalytic activity of rhenium blacks obtained by reduction of rhenium salts in alkali metal-ammonia or amine systems. A review is presented on the chemical, physical and catalytic properties of rhenium, and on the rhenide ion, on the nature of the alkali metal-liquid ammonia system, and the reduction of metallic salts therein. The first reduction system studied was that obtained by dissolving sodium in liquid ammonia. The salts reduced in this system were KReO_4, Re_2O_7 and NH_4ReO_4. The reduction of KReO_4 was unsuccessful, and the heptoxide was difficult to handle. The product …

Some Properties Of Surface Films Formed By Adsorption Of N-Nonadecanoic Acid On Mechanically Activated Metal Surfaces, Tomlinson Fort Jr.

Doctoral Dissertations

The Problem: The work reported here is concerned with the adsorption of n-nonadecanoic acid onto freshly machined metal surfaces. The work done is a direct continuation of that begun by Smith and Allen and continued by McGill whose experimental techniques have largely been adopted. The investigation involves the adsorption of a typical polar organic molecule onto "clean" metal surfaces, prepared under rather rigidly controlled and unique conditions in a system from which the usual surface contaminants are believed to be absent. The purpose of these studies is to gain some insight into the properties of metal surfaces themselves, the …

A Study Of Cholesterol And Lecithin Blood Levels In Rh Sensitized Women Treated With Rh Hapten, Franklyn Lewis

Masters Theses

The Problem And Its Background

Introduction

Perhaps one of the most popular subjects, and a subject which has been discussed a great deal by the layman is that of Rh and Rh incompatibilities.

Landsteiner¹ discovered the Rh property of human blood by means of immune sera prepared with the blood of rhesus monkeys. He was assisted in this work by Wiener², who states that the Rh property was found to be present in about 85% of white individuals, and independent of the blood groups and M-N type. It is these individuals who are referred to as Rh …

The Isomer Distribution In The Sulfonation Of Iodobenzene, Joseph A. Knight

Theses and Dissertations

Using the isotope dilution technique, the distribution of isomers was determined when iodobenzene was sulfonated with sulfur trioxide in liquid sulfur dioxide. The active isotope was S^35. Before this distribution could be established, it was necessary to prepare the pure isomers of iodobenzenesulfonic acid. These were prepared by diazotization of the corresponding aminobenzenesulfonic acids. Since o-aminobenzenesulfonic acid was not readily available, it was necessary that it be synthesized before the diazo reactions could be carried out. Considerable work has been done on the development of a method whereby the bromobenzenesulfonic acids could be synthesized and obtained in pure form. Some …

The Chemical Behavior Of Iodine At Tracer Concentrations, Henry Morris Eiland

Chemistry and Chemical Biology ETDs

Radio-chemistry was introduced as a separate branch of chemistry by Pierre and Marie Curie in 1898. The first radio-chemical process consisted of the separation and identification of the new element Polonium from the uranium ores pitchblende and chalcalite. It is significant that this process involved an amount of material so small that it could be detected only by its intense radioactivity. In the last half-century radio-chemistry has developed into a field of ever increasing diversification.

The Enzymatic Synthesis And Disproportionation Of Galactosyl Oligosaccharides, Carl L. Tipton

Open Access Master's Theses (through 2010)

It was the purpose of this experiment to obtain unequivocal evidence for the suggested structures of the new oligosaccharides and to obtain evidence in support of the transgalactosylation mechanism of action of the enzyme studied.

Five of the galactosyl oligosaccharides produced during the hydrolysis of lactose by an enzyme prepared from Saccharomyces fragilis have been isolated in chromatographically pure form.The three having the highest chromatographic mobilities have been shown to be 3-0-β-D-galactopyranosyl-D-glucose, 6-0-β-D-galactopyranosyl-D-glucose and 6-0-β-D-galactopyranosyl-D-galactose.The positions of the glycosidic linkages in these compounds were determined by use of the lead tetra-acetate oxidation procedure.These three disaccharides have been characterized by measurement …

Gas Chromatography, Ladislav Henry Berka

Honors Theses

Literature pertaining to gas chromotography is reviewed. Methods included are: gas adsorption, gas-liquid partition, and adsorption displacement. After a suitable apparatus was assembled, preliminary work was done by the author, using techniques described in the literature, for the separation and detection of the oxides of nitrogen by gas chromatography

A New Electronic Coulometer For Electroanalytical Chemistry, Jack Donald Merry

Honors Theses

The failure of electroanalytical chemistry to apply extensively the principles of Faraday's laws, has been due primarily to the lack of a direct reading coulometer. The author has investigated several methods of current integration and has concluded that a direct current amplifier with a feedback capacitor shows best promise as a coulometer.

Controlled Cathode Electrodeposition, Walter Adolf Stock

Honors Theses

The purpose of this project was to gather data on electrodeposition with controlled potential, and furthermore, to establish a suitable punched-card system for the recording of such data. In the course of this project, it was discovered that the latter took precedence over the former, since it was deemed more vital to have a good punched-card system with fewer data than more data rendered difficult to refer to because of an inefficient system.

A Calorimetric Investigation Of Zirconium, Titanium, And Zirconium Alloys From 60 To 960°C, James L. Scott

Masters Theses

Structural materials for nuclear reactors must meet three stringent conditions: they must have adequate mechanical properties at the operating temperature, they must be corrosion resistant to the heat transfer medium (air, water, or alkali metals), and they must not absorb neutrons excessively. This last requirement is a particularly stringent one, for it is met by only four accessible metals: aluminum, magnesium, beryllium, and zirconium, as Table I shows.

For reactors which operate at low temperatures, aluminum serves as an excellent constructional material, but it cannot be used for more efficient high-temperature reactors, because of its low elevated temperature strength associated …

Alkylation Of Phenol, Donald Harry Paskovich

Honors Theses

The object of this research is to relate the structure of products obtained from alkylation of phenol and the rearrangement of alkyl phenol ether to that of known compounds. Means of comparison are the preparation of derivatives and infrared analysis. By so doing, it may be possible to advance facts that can be used in the determination of a mecanism of reaction.

Synthesis Of Β-Methylene Piperidine And Reactions Of Its Derivatives, Robert Peter Yunick

Honors Theses

This research is directly aimed at synthesis of tertiary amines which might be used in bringing about this optical resolution by means of two principles: (1) enclose the tri-valent nitrogen atom in a stable ring structure, and (2) bring about stabilization of the third nitrogen substituent by means of hydrogen bonding forces of this substituent by means of hydrogen bonding forces of this substituent with some function on the nitrogen containing ring.

A Study Of The Density And Molecular Species Of Polonium And Tellurium Vapor, Angelo L. Giorgi

Chemistry and Chemical Biology ETDs

The purpose of this investigation was to determine the nature of the species of polonium and tellurium in equilibrium in the vapor phase at temperatures ranging from 422 degrees to 1013 degrees C. for polonium and from 512 degrees to 880 degrees C. for tellurium. Such information was based on measurements of the variation of vapor pressure and vapor density with temperature. The results of this investigation suggest that both polonium and tellurium exist as diatomic molecules in the vapor phase over the aforementioned temperature ranges.

Studies Of The Chemistry Of Systems Involving Water, Hydrogen Peroxide And Plutonium (Iv) Nitrate In Tri-N-Butyl Phosphate, Lawrence J. Mullins Jr.

Chemistry and Chemical Biology ETDs

The reaction of tri-n-butyl phosphate (TBP), with water and hydrogen peroxide is studied by means of distribution experiments. The solubility of water in TBP-hexane, at low TBP concentrations, is consistent with the premise that H₂O•TBP is the principal solvate species formed at low hydrogen peroxide concentrations. The distribution data at high hydrogen peroxide concentrations indicate that another species such as H₂O₂•TBP is also present.

A Radiochemical Investigation Of Short-Lived Selenium And Bromine Fission Products, James Edward Sattizahn Jr

Chemistry and Chemical Biology ETDs

From a sample of uranium bombarded with neutrons, Hahn and Strassmann, in 1939, separated four radioactive products which followed alkaline earth chemistry and were therefore tentatively attributed to isotope of radium. Each of these products decayed to a daughter activity which could be precipitated along with lanthanum; the daughter activities were then assumed to be isotopes of actinium. Subsequently, by accepted methods of fractional crystallization and precipitation, the "radium" and "actinium" isotopes were identified unequivocally as isotopes of barium and lanthanum, respectively. Within a relatively short time there were found more such radioactive products, which were identified as isotopes of …

Behavior Of Indium At Tracer Concentrations, Katheryn L. Lawson

Chemistry and Chemical Biology ETDs

The increase in number and availability of radioisotopes that can be produced in the carrier-free state has offered practical means of investigating the chemical behavior of substances at extremely low concentrations. The working region of concentrations, which may extend to less than 10^-14 molar, is generally fixed only by the half-life of the radio-element and the nature of the radiation.

Volume 3, Number 1 - May 1957

The Entropy

The Entropy (also published as the Providence College Journal of Physics and Chemistry) was an undergraduate scholarship journal published by the Phi Chi Club of Providence College. (Volume 3, Number 1 - May 1957 - 19 pages in total.)

The Dehydrocyclization Of Normal Heptane To Toluene With Supported Rhenium, Platinum And Molybdenum Catalysts, Robert R. Beishline

Theses and Dissertations

The dehydrocyclization activity of supported platinum, molybdenum and rhenium catalysts was studied by determining the toluene yield from n-heptane as a function of temperature and metal concentration in the catalyst. The support was 100 to 200 mesh alumina. Metal concentrations of 0.01% to 1.0% platinum, 0.1% to 2.0% molybdenum and 0.1% to 2.5% rhenium were studied in the temperature range from 500° to 600° C. Platinum was shown to be superior to both molybdenum and rhenium at all temperatures and metal concentrations investigated. The rhenium data were somewhat erratic, but showed rhenium to be a poor dehydrocyclization catalyst. The apparatus, …

The Exchange Of Chlorine Between Hydrogen Chloride And Acetyl Chloride In The Vapor Phase, Warren J. Niell

Chemistry and Chemical Biology ETDs

The aim of chemical kinetics is to predict the rates of chemical reactions, to determine the factors influencing the reaction rate, and to postulate a suitable reaction mechanism.

The Chemical Effects Of Gamma Radiation On Halogenated Methanes, Clifford G. Shultz

Chemistry and Chemical Biology ETDs

At its inception, the present work was to consist of testing a number of halogenated organic compounds for sensitivity to radiation. Some of the compounds which showed a relatively high sensitivity to radiation were to be investigated more thoroughly with a view toward a) the development of a sensitive radiation detection device and b) elucidation of the reactions involved in the radiolytic decomposition of the compounds. Some screening had already been done and several systems involving chloroform, bromoform and carbon tetrachloride had been investigated and their results reported. The experiments on the chloroform- and bromoform- crystal violet systems showed a …

The Synthesis And Proof Of Structure Of 2, 4-Dimethyl-6-Hydroxynicotinamide, R. E. Buckles, A. Langsjoen, L. Mueller, I. Svendsen

Journal of the Minnesota Academy of Science

No abstract provided.

Vinyl Polymers Containing Acrylic Acid-1-C, Courtland L. Agre

Journal of the Minnesota Academy of Science

No abstract provided.

The Use Of P In Preparing Radioautographs, R. B. Hastings, James Dimond

Journal of the Minnesota Academy of Science

No abstract provided.