Physical Sciences and Mathematics Commons^™

Cholinesterase Based System For Fentanyl Detection, Alyssa Shoemaker

Legacy Theses & Dissertations (2009 - 2024)

Opioids and other illicit drugs have become a very prevalent problem across the world, especially in the United States. In fact, every day more than 130 people die from an opioid overdose. Despite many public warnings explaining the risks of opioid and drug use, the epidemic has continued to grow. As illicit drugs are becoming more rampant in society, law enforcement officers need a reliable, rapid, and non-invasive method to detects when someone may be on drugs, for example while driving, and to assess unknown powders or substances when presented at a crime scene containing drugs. Currently, at traffic stops …

Optimization Of Gradient Chromatofocusing For The Protein Separation And Lc-Ms/Ms Determination Of Ngp1-01 In Mouse Serum, Brain, And Retina, Harini Jogiraju

ETD Archive

No abstract provided.

Gradient Chromatofocusing And Reversed Phase Hplc In Protein Analysis And Lc-Ms/Ms Determination Of Thiazolidinedione Nl-1 In Mouse Serum And Brain, Kiran K. Pedada

ETD Archive

No abstract provided.

Intragroup Separation Of Trivalent Lanthanides And Actinides For Neutron Capture Experiments In Stockpile Stewardship Sciences, Narek Gharibyan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Knowledge of low-energy cross sections for stable and unstable nuclei in neutron-, γ- and ion induced reactions is important in both the simulation and radiochemistry diagnosis of nuclear device performance. This dissertation explores extraction chromatography and ion chromatography methods for the intragroup separation of trivalent actinides and lanthanides in support of cross section measurements for isotopes of interest. For trivalent actinides, americium (Am(III)) and curium (Cm(III)), separation is necessary to assist in experiments related to the measurement of neutron capture cross section for ²⁴¹ Am and the production of ^{242 m} Am/^242g Am isomeric ratio. Extraction chromatography resins …

Extraction Chromatographic Studies Of Rutherfordium And Dubnium Homologs, Megan E. Bennett

UNLV Theses, Dissertations, Professional Papers, and Capstones

Studying the chemistry of transactinide elements does not only allow for these elements to be properly placed in the Periodic Table, but it also permits for the extrapolation of the electronic structure based upon the position of the element in the Periodic Table. In addition it enable for the assessment of the role that relativistic effects play in the chemical behavior of the heaviest elements. An improved understanding of the role of relativistic effects in chemistry of the heaviest elements allows for a better understanding of the fundamentals principles that govern the Periodic Table. In order to investigate the chemistry …

Preparation And Characterization Of Extraction Chromatography Resins Using N-Donor Extractants For Trivalent Actinide And Lanthanide Separations, Christopher L. Klug

UNLV Theses, Dissertations, Professional Papers, and Capstones

Actinide and lanthanide elements exist in the geosphere and biosphere due to both natural abundances and anthropogenic activities. The investigation of the presence and transport of actinides through the environment is of great scientific interest. In order to prepare environmental samples for precise measurements, the individual actinides must be separated from the chemically similar lanthanides, and from neighboring actinides. Existing extraction chromatography resins are either poorly suited for this separation, have bleeding problems, are not reusable, or fail the CHON principle. In an effort to resolve these issues, malonamides and N-donor extractants from the BTP and BTBP classes of solvent …

Development Of A Novel Gradient Chromatofocusing Tandem Mass Spectometry Technique For The Determination Of Cationic Compounds In Biofluids;Identification Of Caspace 3 Cleavage Sites Of Nhe-1 By High Performance Liquid Chromatography- Mass Spectrometry, Jianhua Tang

ETD Archive

In Part I, work was done to develop a novel gradient chromatofocusing liquid chromatography-tandem mass spectrometry (MS/MS) technique for the determination of ionic compounds in biological matrix. The analysis of ionic compounds poses a great challenge to current LC-MS techniques, due to the fact that there is little or no retention. These ionic compounds are eluted at almost the same time as biological matrix, which is normally directed to waste prior to connecting to the mass spectrometer. A review of current LC-MS techniques for ionic compounds is given in Chapter 1. They all have advantages and disadvantages. To retain and …

A Pulse Gas Chromatographic Method For Determining The Dispersion And Surface Area Of Co Oxidation Catalysts, Susan Kay Ohorodnik

Chemistry & Biochemistry Theses & Dissertations

Catalysts composed of platinum and/or palladium on tin(IV) oxide supports with or without silica gel have been developed for the recombination of carbon monoxide and oxygen to form carbon dioxide for use in carbon dioxide lasers. A pulse gas chromatographic method has been developed to measure the chemisorption properties of the catalysts. From the chemisorption measurements, the active surface area and dispersion of the catalysts have been determined.

Determination Of N,N'-Diphenylguanidine In Biological Tissues And Fluids Using High Pressure Liquid Chromatography, Edward Sidney Hunter Iii

Chemistry & Biochemistry Theses & Dissertations

N,N'-Diphenylguanidine (DPG) is a potentially toxic compound used in the vulcanization of rubber products. Distribution of DPG in hybrid mice (C57BL/6J interbred with DAB₂) was determined following intraperitoneal injection. Urine, fecal material, whole blood and tissues were collected at various times after administration of DPG and the extracts analyzed for DPG by high pressure liquid chromatography. Recovery of DPG from spiked urine and whole blood exceed 90%, however, the recovery of DPG from spiked tissue samples was approximately 70%.

DPG concentration in whole blood reached a maximum within ten minutes and rapidly decreased through 180 minutes after administration …