Physical Sciences and Mathematics Commons^™

Synthesis And Characterization Of Hyaluronic Acid Based Biomaterials For Drug Delivery And Virus Modification, Amanda Wagner

Theses and Dissertations

In this thesis, hyaluronic acid based biomaterials are studied. The properties and potential applications of these polymers are characterized and discussed.

In Chapter 1, biomaterials are introduced as well as hydrogels and nanogels. Hyaluronic acid is highlighted as a remarkable bio-polymer. The overall objectives of my research are also discussed.

Chapter 2 is focused around trials for utilizing graphene oxide as a nanomaterial for controlling the drug release of an aromatic compound. Hyaluronic acid based hydrogels were synthesized as a delivery vessel. The results of the drug release profiles are examined and discussed.

A different direction is taken in Chapter …

Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez

University of the Pacific Theses and Dissertations

In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switches in various trans-2-aminocyclohexanol derivatives. By changing the groups on the amine nitrogen, these models provided a wide pH range in which a switch can occur. The pH-induced switch of conformation was monitored by 1H-NMR spectroscopy. The models were also incorporated into the bilayer membrane of liposome structures and tested for their ability to disrupt their membrane upon their conformational flip induced by a decrease in pH.

In this work, the amide bond has been studied as a molecular switch and various amide derivatives have been tested for …