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Full-Text Articles in Physical Sciences and Mathematics
Investigations Into Factors Affecting The Wpd-Loop In The Protein Tyrosine Phosphatases Yoph And Ptp1b, Gwendolyn Moise
Investigations Into Factors Affecting The Wpd-Loop In The Protein Tyrosine Phosphatases Yoph And Ptp1b, Gwendolyn Moise
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The research in this dissertation documents connections between the primary amino acid sequence of proteins, the dynamics of proteins, and their catalytic function. This research project studied two proteins called protein-tyrosine phosphatases (PTPs): the human enzyme PTP1B, and the bacterial enzyme YopH. PTP1B is a human enzyme that down regulates the insulin receptor on the outer cellular membrane, and causes the insulin receptor to be less responsive to insulin. A deeper knowledge of how PTP1B is different from other human PTPs might be useful in designing drugs to increase insulin sensitivity in diabetics. Yersinia Pestis is the bacteria that caused …
Investigation Of Structure And Dynamics Of Deep Eutectic Solvent Using Infrared Spectroscopy, Yaowen Cui
Investigation Of Structure And Dynamics Of Deep Eutectic Solvent Using Infrared Spectroscopy, Yaowen Cui
LSU Doctoral Dissertations
Deep Eutectic Solvents (DES) are liquid mixtures prepared from solids. As a new class of green solvents, DES not only share many properties with ionic liquids, such as low volatility, conductivity, tailorable constituents, but also have some advantages over ionic liquids, like easier preparation, safe and inexpensive materials, biodegradability, low toxicity, and excellent solubility. Because of those attractive properties, DES has been studied in many scientific and engineering fields. However, compared with the great number of studies of the application, many questions about structure and dynamics of DES are unanswered. To shed light on the mystery of solvent or solvation …