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Full-Text Articles in Physical Sciences and Mathematics
The Chemistry And Biology Of Iron-Scavenging Natural Products From Pathogenic Acinetobacter Baumannii, Justin Shapiro
The Chemistry And Biology Of Iron-Scavenging Natural Products From Pathogenic Acinetobacter Baumannii, Justin Shapiro
Arts & Sciences Electronic Theses and Dissertations
Multidrug resistant (MDR) Gram-negative bacteria represent a global health crisis. Traditional antibiotics create selective pressure and breed resistance, making our current drugs less and less effective. Targeting of bacterial virulence factors has gained interest as an alternative strategy to potentially circumvent this problem. Virulent Acinetobacter baumannii synthesize and secrete pre-acinetobactin, a small molecule metal chelator that scavenges life-sustaining iron and is critical for establishing infection. The work described herein sheds light on the unusual properties of a non-enzymatic isomerization from pre-acinetobactin to acinetobactin and proposes a siderophore-swapping mechanism by which A. baumannii expands its pH window for virulence. Knowledge from …
Mild Hydrofunctionalizations Of Olefins Using More Cost-Effective Metal Catalysts, Alexander James Villani-Gale
Mild Hydrofunctionalizations Of Olefins Using More Cost-Effective Metal Catalysts, Alexander James Villani-Gale
Dissertations
The focus of this dissertation is the study of alkene hydroaylation reactions. In the first chapter, a review of the relevant literature concerning zinc- and iron-catalyzed hydroarylation of unsaturated bonds is presented. In chapter two, the development of a zinc-catalyzed hydroarylation of alkenes is presented, which is quickly followed by a detailed investigation into the probable mechanism. Chapter three discusses the development of an iron/silver-catalyzed arene prenylation reaction, followed by the development of an iron/zinc-catalyzed arene prenylation reaction. The final section of chapter three discusses the adaptation of the iron/zinc-catalyzed arene prenylation into an undergraduate organic teaching laboratory.