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Full-Text Articles in Physical Sciences and Mathematics
Prevention Of Iron- And Copper-Mediated Oxidative Dna Damage By Neurotransmmitters And Related Compounds: Evidence For Metal Binding As An Antioxidant Mechanism, Carla Garcia
All Theses
An array of health concerns have been attributed to oxidative DNA damage from the hydroxyl radical (*OH), and the presence of the most biologically available metals iron and copper perpetuate the production of this radical through the Fenton and Fenton-like reactions, respectively. The concentrations at which flavonol and polyphenol antioxidants prevent 50% of DNA damage (IC50) were measured using gel electrophoresis assays upon Fe(II)/H2O2- and Cu(I)/H2O2-mediated DNA damage (Chapter 2). Results show that catechol- and gallol-containing antioxidants differ greatly in preventing DNA damage by Cu(I)/H2O2, compared to Fe(II)/H2O2, behavior that was explained using electron paramagnetic resonance spectroscopy. Semiquinone and other …
Supramolecular Organization Of Nanoparticles, Brenda M. Porta Linnell
Supramolecular Organization Of Nanoparticles, Brenda M. Porta Linnell
Open Access Theses & Dissertations
The study of supramolecular structures with nano-architectures has become an active area of research in recent years. They have the potential to generate functional materials with applications in medicine and emerging technologies. In this dissertation, the supramolecular organization of gold nanoparticles (AuNP) and other nano-scale structures such as discrete styrene-based polymers was investigated. The synthesis and characterization of metal-mediated AuNPs systems using pendant ligands on the AuNP such as 11-diethylenetriamine-undecane-1-thiol, 11-Mercapto-undecanoic acid [2-(2-amino-ethylamino)-ethyl]-amide, Bis(11-oxo-nicotinic acid, undecine)disulfide, and 11-mercaptoundecanoic acid, and using Cu(II) to mediate the formation of supramolecular AuNP systems with sizes of 200 nm ¡V 3 fÃ?m, are …
Guanidines, Amidines And Carbamides As Novel Sigma Receptor Ligands For Post-Stroke Therapeutics, Michelle Yolanda Cortes-Salva
Guanidines, Amidines And Carbamides As Novel Sigma Receptor Ligands For Post-Stroke Therapeutics, Michelle Yolanda Cortes-Salva
USF Tampa Graduate Theses and Dissertations
Stroke is the 3rd leading cause of death in the United States. For this reason, it has become our goal to find a drug that is capable of reestablishing intracellular and extracellular Ca+2 flux upon direct binding to the sigma receptor, which can be delivered easily and efficiently. Our active research focuses the development of guanidine analogues that can serve as therapeutic drugs which target sigma 1 and sigma 2 receptors having a direct effect on Ca+2 levels on the cell. The use of symmetrical guanidine analogues such as N,N'-di-o-tolyl guanidine (o-DTG) as therapeutic drugs for ischemic …