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Enantiomers -- Separation<br />Chromatographic analysis<br />Optical isomers<br />Optical isomers -- Biotechnology
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Full-Text Articles in Physical Sciences and Mathematics
New Bio-Analytical Separations Utilizing Chiral Mobile Phase Additives In Thin Layer Chromatography And Chiral Stationary Phases In High Performance Liquid Chromatography, Jo Dee Duncan
Doctoral Dissertations
"The problem addressed by this dissertation is the separation of optical isomers in commercial as well as biological samples. The chromatographic separation of enantiomers is an important and rapidly developing field of study. Chiral separations of pharmaceutical compounds and important organic intermediates in high performance liquid chromatography (HPLC) and thin layer chromatography (TLC) were achieved. Two methods were employed for the direct liquid chromatographic resolution of chiral analytes: chiral stationary phases (CSPs) and chiral mobile phase additives (CMAs). Native and derivatized ß-cyclodextrins (ß-CD) were used as chiral stationary phases in reverse phase and normal phase HPLC, respectively. This study marked …