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Full-Text Articles in Physical Sciences and Mathematics
Greener Synthesis Of Chlorophosphazenes, Andrew Mcgee
Greener Synthesis Of Chlorophosphazenes, Andrew Mcgee
Williams Honors College, Honors Research Projects
This project will attempt to synthesize chlorophosphazene molecules in the absence of solvents by using mechanochemical techniques in order to create a more environmentally friendly synthesis route. In this pursuit, various parameters will be changed including the milling ball to reagent ratios, the molar ratios of the reactants, and the addition of different catalysts. The products of each reaction will be characterized in order to determine success. This work builds upon existing efforts to utilize mechanochemical techniques in main group chemistry. The output of this project will be a report in ACS style and a poster to be presented for …
Synthesis, Characterization, And Biological Activity Of Imidazolium Salts, David Weader
Synthesis, Characterization, And Biological Activity Of Imidazolium Salts, David Weader
Williams Honors College, Honors Research Projects
Nonmuscle invasive bladder cancer (NMIBC) inflicts thousands of Americans annually, and is typically treated with the immunotherapy BCG. However, due to a BCG shortage, there is a new need for novel treatments of NMIBC. Addressing this issue, several imidazolium salt derivatives were synthesized and characterized with the intent of treatment within the bladder. These imidazolium salts were tested against different human bladder cancer cell lines in vitro to determine their reactivity and cytotoxicity. Among these results are GI50 concentrations for each drug, which is the concentration of drug needed to see growth inhibition in 50% of treated cells. Previous published …
Synthesis Of Bio-Based Polymer Products, Joshua Sukie
Synthesis Of Bio-Based Polymer Products, Joshua Sukie
Williams Honors College, Honors Research Projects
The project covers the synthesis of two bio-based polymers. One aspect of the research investigates the synthesis of materials for use in vegetable oil-based UV-curable coating, and the subsequent polymerization of the materials into a coating film. The second aspect of the research follows the synthesis of a functionalized cellulose material for use as a reinforcer in a vegetable oil-based composite. Both products are subsequently analyzed by various methods.