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Full-Text Articles in Physical Sciences and Mathematics
Structural Studies Of Blood Coagulation Factor Viii In Complexes With Inhibitory Antibodies, Rachel Werther
Structural Studies Of Blood Coagulation Factor Viii In Complexes With Inhibitory Antibodies, Rachel Werther
WWU Graduate School Collection
Normal blood clotting is regulated by blood plasma protein factors in a blood coagulation cascade. Deficiency in one of these proteins, Factor VIII (FVIII), causes the disease hemophilia A, in which the patient is unable to form blood clots. Treatment of hemophilia A involves the infusion of FVIII, and the most common complication in this treatment is the development of antibodies against the therapeutic infusions. Two mouse monoclonal anti-human antibodies, 3E6 and G99, were used as models of inhibitory action against FVIII by binding to the C-terminal C2 domain. A classical antibody, 3E6, blocks the ability of FVIII to bind …
Performance Of Oriented Fluorophore Luminescent Solar Concentrators, Tristan Butler
Performance Of Oriented Fluorophore Luminescent Solar Concentrators, Tristan Butler
WWU Graduate School Collection
Solar power is likely to play a significant role in the future of fossil fuel alternatives. In order to maximize its impact, the cost of solar power must be competitive with fossil fuels on the global energy market. Luminescent Solar Concentrators are an attractive technology that can potentially reduce the cost of solar power. LSCs utilize cheap materials and no moving parts to concentrate light, however the amount of solar concentration is limited by loss mechanisms inherent in LSCs. One potential method to improve the efficiency of LSCs is through the use of oriented fluorophores. Based on theory presented in …
The Isolated Sixth Gelsolin Repeat Of Villin Has A Calcium-Regulated Structure And Lacks Capacity To Bind F-Actin, Jacob A. Brockerman
The Isolated Sixth Gelsolin Repeat Of Villin Has A Calcium-Regulated Structure And Lacks Capacity To Bind F-Actin, Jacob A. Brockerman
WWU Graduate School Collection
Villin is a modular, epithelial, actin binding protein responsible for the regulation of microvilli in the brush border region of the small intestine and kidney. Villin is regulated by tyrosine phosphorylation, Phosphatidylinositol 4,5-bisphosphate and calcium concentration. These signal molecules control villin's multifunctionality and allow it to switch among its several opposing functional roles. Villin can cleave, nucleate, cap and bundle F-actin. This is achieved through villin's six gelsolin-like domains which are connected by a 40 residue linker sequence to a novel C-terminal headpiece domain (HP). It is known that the HP forms a calcium insensitive F-actin binding site that is …