Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Physical Sciences and Mathematics
Copper-Catalyzed Diboration Of Ketones: Facile Synthesis Of Tertiary A-Hydroxyboronate Esters, Melissa Mcintosh
Copper-Catalyzed Diboration Of Ketones: Facile Synthesis Of Tertiary A-Hydroxyboronate Esters, Melissa Mcintosh
WWU Graduate School Collection
The versatility of the C-B bond in organic synthesis has led to extensive development of new methods for the selective incorporation of boron into organic substrates. The incorporation of boron substituents alpha to heteroatoms provides direct entry into substrates analogous to those formed and utilized in the Matteson homologation reaction. Our group has explored the diboration of various ketones using the (ICy)CuOt-Bu catalyst developed by Sadighi and co-workers. We found that (ICy)CuOt-Bu could be generated in situ using 3 mol % (ICy)CuCl and 5 mol% NaOt-Bu (Scheme 1). This catalyst system was shown to cleanly afford the diboration of various …
Structural Characterization Of Cytoskeleton Regulating Protein Villin And Its C-Terminal Modular Domains, Danielle A. Pfaff
Structural Characterization Of Cytoskeleton Regulating Protein Villin And Its C-Terminal Modular Domains, Danielle A. Pfaff
WWU Graduate School Collection
Villin is a modular protein that regulates F-actin bundles in the microvilli of absorptive epithelial cells in the intestine. At low (10-100 nM) calcium levels, Villin is an F-actin bundling agent supporting the specialized brush border membrane of the absorptive epithelium. At intermediate micromolar calcium levels, Villin nucleates and caps the barbed ends of F-actin and in high (> 100 μM) calcium Villin is an F-actin severing agent (Bretsher & Weber, 1980; Glenney et al., 1980, 1981; Mooseker et al. 1980). The amino acid sequence of Villin has seven modular domains. The first six Villin domains (D1-D6) form a "core" …
Ambient Pressure Organic Semiconductor Thin Film Growth By Ambient Axisymmetric Spray, Kevin A. (Kevin Anthony) Bufkin
Ambient Pressure Organic Semiconductor Thin Film Growth By Ambient Axisymmetric Spray, Kevin A. (Kevin Anthony) Bufkin
WWU Graduate School Collection
Interest in using organic semiconductors in applications such as large area displays, photovoltaic devices, and radio frequency identification tags stems in part from their prospects for enabling significantly reduced manufacturing costs compared to traditional inorganic semiconductors. However many of the best performing prototype devices produced so far have involved expensive or time-consuming fabrication methods, such as the use of single crystals or thin films deposited under high vacuum conditions. This thesis examines a new approach for growing low molecular weight organic crystalline films at ambient conditions based on an organic vapor-liquid-solid growth (OVLS) mechanism using thermotropic nematic liquid crystal (LC) …
Activation And Inhibition Of Gtpase Translation Factors On The Prokaryotic Ribosome, Justin D. Walter
Activation And Inhibition Of Gtpase Translation Factors On The Prokaryotic Ribosome, Justin D. Walter
WWU Graduate School Collection
Throughout all domains of life, each protein in a cell is synthesized by a remarkable biomolecular machine called the ribosome, in a process referred to as translation. This process is regulated by proteins called translation factors, several of which belong to the GTPase superfamily of enzymes which require the binding and subsequent hydrolysis of guanosine 5'-triphosphate (GTP) to execute their function. In contrast to the regulatory role of translation factors, protein biosynthesis is inhibited by several naturally occurring antibiotics. While our understanding of translation has been revolutionized by the recent elucidation of atomic-resolution x-ray crystal structures of the ribosome trapped …