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Full-Text Articles in Physical Sciences and Mathematics
Reduction Of Sugar Lactones To Lactols With Super-Hydride, Andersson Sanchez
Reduction Of Sugar Lactones To Lactols With Super-Hydride, Andersson Sanchez
Undergraduate Research at FIU (URFIU) Conference
Reduction reactions are an important area of study in organic synthesis and are used to synthesize a variety of compounds. In particular, the reduction of lactones to their respective lactols or hemiacetals is important for the synthesis of biologically active modified carbohydrates which are often used in drug design. The reduction of the sugar-based lactones to their respective lactols with lithium triethyl borohydride (LiEt3BH) will be the focus of this project. The efficiency of this reagent to reduce sugar lactones to sugar hemiacetals (lactols) will be studied under different reaction parameters to develop an efficient protocol for its uses. The …
Examining The Effects Of The Binding Of The Carcinogen 4-Nitroquinoline-1-Oxide To Dna Phix174 On Dna Structure Using Mung Bean Nuclease And Topoisomerase I Assays, Elizabeth Tinoco
Undergraduate Research at FIU (URFIU) Conference
Optical titration studies, NMR studies and studies with DNA oligonucleotides have suggested that the carcinogen 4-nitroquinoline-1-oxide binds to DNA with marked sequence selectivity and cooperativity and that its binding affects the reactivity of enzymes with DNA. The observed cooperativity and enzyme effects suggest that the binding alters DNA structure. Using Mung Bean nuclease, an enzyme that recognizes regions of altered DNA structure, and Topoisomerase I, an enzyme which probes the unwinding of DNA, the binding effects of NQO to DNA phiX174 structure will be observed. To examine the effects of NQO on phiX 174, samples of supercoiled DNA are incubated …
The Investigation Of The Analysis Of Flakka, Carolina Brea
The Investigation Of The Analysis Of Flakka, Carolina Brea
Undergraduate Research at FIU (URFIU) Conference
The synthetic drug craze, which began taking root just a few years ago, has been sweeping the nation. South Florida in particular has become an epicenter for synthetic drug use with its lively nightlife and vibrant club scenes. As of today, one of the most popular, and equally dangerous drugs, on the market is α-PVP, commonly known as Flakka. Flakka is unique in its domination of Miami-Dade and Broward communities while hardly appearing anywhere else in the country. Flakka’s influence in South Florida will be investigated in order to shed light on the origins of its popularity, its effects on …
Bio-Inspired Dinuclear Copper Oxygenation Catalysts: Synthesis, Characterization, And Reactivity Studies, Susana Herrera
Bio-Inspired Dinuclear Copper Oxygenation Catalysts: Synthesis, Characterization, And Reactivity Studies, Susana Herrera
Undergraduate Research at FIU (URFIU) Conference
Dinuclear copper assemblies are encountered in the active centers of various oxidases involved in the oxidation of organic substrates by dioxygen. The role of the protein backbone in these metalloproteins is to hold the two Cu-centers in close proximity as to allow a two-electron oxidation of the Cu (I) rest state to the Cu (II) catalytically active form. The objective is to synthesize a dinuclear copper complex by different approaches using a pyrazole ligand and introducing substituents on the bipy site. Furthermore, the investigation of the reactivity of the Cu (I) complex towards oxidants other than dioxygen and the reactivity …
Conformational Dynamics In Vertebrate Hexa-Coordinate Hemoglobins, Jessica Lopez
Conformational Dynamics In Vertebrate Hexa-Coordinate Hemoglobins, Jessica Lopez
Undergraduate Research at FIU (URFIU) Conference
Cytoglobin, a recently discovered hemeprotein, is part of a globin protein family including hemoglobin, myoglobin, and neuroglobin. Numerous studies have reported the role of cytoglobin in tissue protection as well as a tumor suppression. However, the molecular mechanism of how cytoglobin carries out its protective functions under physiological and pathological conditions remains unclear. The cytoglobin structure includes a globin core that is homologous to myoglobin and a 20 amino acid residue extension at the N terminus and the C terminus that is unique among vertebrate globins. This study aims to provide a molecular insight into the cytoglobin folding mechanism with …