Physical Sciences and Mathematics Commons^™

From Florida To Antarctica: Dereplication Strategies And Chemical Investigations Of Marine Organisms, Matthew A. Knestrick

USF Tampa Graduate Theses and Dissertations

In the fight against disease and illness, nature has provided mankind some of our best therapeutics in the form of secondary metabolites. The plant, fungi and animal phyla inhabiting the Earth produce diverse and unique chemistry that can be used in our fight against disease. In the growing threat of drug resistance and pathogen evolution, the field of natural products chemistry strives to explore new biological and chemical diversity sources, and develop innovative methodology to identify and isolate new chemistry faster than ever.

The dissertation herein presented is one such effort to find new, bioactive chemistry from the marine environments. …