Physical Sciences and Mathematics Commons^™

Chemical Investigations Of Fungal Natural Products For Drug Discovery, Danielle H. Demers

USF Tampa Graduate Theses and Dissertations

Natural products have, historically, played an important role in drug discovery. Nevertheless, drug resistance, pathogen evolution, and global climate change threaten human health and nearly all current anti-infective treatments on the market today. It is undeniable that new drug discovery efforts are needed with increasing urgency.

Bolstered by a rich history of discovering treatments in the world around us, natural products chemists continue to look to the environment with increasing understanding and emerging technologies that allow efficient, effective isolation of new chemical entities. This thesis will describe one such endeavor.

Focusing on fungal natural products, herein is described the isolation …