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Full-Text Articles in Physical Sciences and Mathematics
Algaecidal And Oxidative Effects Of Metal-Free Phthalocyanine Beta Tetra-Substituted With Sodium 2-Mercaptoethanesulfonate, Hati̇ce Tunca, Sena Çağatay Özpinar, Ayşe Gül Tekbaba, Tuğba Ongun Sevi̇ndi̇k, Ali̇ True, Armağan Günsel, Ahmet Turgut Bi̇lgi̇çli̇, Meryem Ni̇lüfer Yaraşir
Algaecidal And Oxidative Effects Of Metal-Free Phthalocyanine Beta Tetra-Substituted With Sodium 2-Mercaptoethanesulfonate, Hati̇ce Tunca, Sena Çağatay Özpinar, Ayşe Gül Tekbaba, Tuğba Ongun Sevi̇ndi̇k, Ali̇ True, Armağan Günsel, Ahmet Turgut Bi̇lgi̇çli̇, Meryem Ni̇lüfer Yaraşir
Turkish Journal of Chemistry
In this study, a water-soluble metal-free phthalocyanine (SPC) containing sodium 2-mercaptoethanesulfonate substituents at the peripheral positions was used to investigate the algaecidal properties and oxidative effects on the growth of two microalgal species, Arthrospira platensis and Chlorella vulgaris. Although OD at 560 nm and chlorophyll-a content were decreased in Arthrospira platensis during 7 days depending on dose and time, increases in both OD at 750 and chlorophyll-a content at 8 ppb (parts per billion) concentration on the 7th day were observed in Chlorella vulgaris. However, total SOD (superoxide dismutase) and GR (glutathione reductase) enzyme activity of A. platensis cultures did …
Biological Potential Of Copper Complexes: A Review, Jamshaid Ashraf, Muhammad Asad Riaz
Biological Potential Of Copper Complexes: A Review, Jamshaid Ashraf, Muhammad Asad Riaz
Turkish Journal of Chemistry
This review comprises the inorganic compounds particularly metal coordinated complexes, as drugs play a relevant role in medicinal chemistry. It has been observed that copper complexes are potentially attractive as medicinal importance. In this review, the most remarkable achievements of copper complexes undertaken over the past few decades as antimicrobial, antioxidant, enzyme inhibition activity, and anti-cancer agents are discussed. This work was motivated by the observation that no comprehensive surveys of the diversity of biological activities of copper complexes were available in the literature.
Synthesis Of Hydroxy Benzoin/Benzil Analogs And Investigation Of Their Antioxidant,Antimicrobial, Enzyme Inhibition, And Cytotoxic Activities, Nuretti̇n Yayli, Gözde Kiliç, Gonca Çeli̇k, Nuran Kahri̇man, Şeyda Kanbolat, Ari̇f Bozdeveci̇, Şengül Alpay Karaoğlu, Rezzan Ali̇yazicioğlu, Hasan Erdi̇nç Selli̇tepe, İnci̇ Seli̇n Doğan, Ali̇ Aydin
Synthesis Of Hydroxy Benzoin/Benzil Analogs And Investigation Of Their Antioxidant,Antimicrobial, Enzyme Inhibition, And Cytotoxic Activities, Nuretti̇n Yayli, Gözde Kiliç, Gonca Çeli̇k, Nuran Kahri̇man, Şeyda Kanbolat, Ari̇f Bozdeveci̇, Şengül Alpay Karaoğlu, Rezzan Ali̇yazicioğlu, Hasan Erdi̇nç Selli̇tepe, İnci̇ Seli̇n Doğan, Ali̇ Aydin
Turkish Journal of Chemistry
In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer …
Cytotoxic And Apoptotic Effects Of Hypericum Androsaemum On Prostate Adenocarcinoma(Pc-3) And Hepatocellular Carcinoma (Hep G2) Cell Lines With Identification Of Secondarymetabolites By Lc-Hrms, Nurdan Yazici Bektaş, Ezgi̇ Ersoy, Mehmet Boğa, Tuğçe Boran, Ercan Çinar, Gül Özhan, Ahmet Ceyhan Gören, Esra Eroğlu Özkan
Cytotoxic And Apoptotic Effects Of Hypericum Androsaemum On Prostate Adenocarcinoma(Pc-3) And Hepatocellular Carcinoma (Hep G2) Cell Lines With Identification Of Secondarymetabolites By Lc-Hrms, Nurdan Yazici Bektaş, Ezgi̇ Ersoy, Mehmet Boğa, Tuğçe Boran, Ercan Çinar, Gül Özhan, Ahmet Ceyhan Gören, Esra Eroğlu Özkan
Turkish Journal of Chemistry
The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatographyhigh resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of the plant. Cytotoxic activity was evaluated by MTT assay, and apoptosis induction abilities on human prostate adenocarcinoma (PC-3), and hepatocellular carcinoma (Hep G2) cell lines. Accordingly, major secondary metabolites were found as hederagenin (762 ± 70.10 μg/g) in the leaves dichloromethane (LD), herniarin (167 ± 1.50 μg/g) in fruit dichloromethane (FD), (-)-epicatechin (6538 ± 235.36 μg/g) in the leaves methanol (LM), (-)-epigallocatechin gallate (758 ± 20.46 μg/g) in the fruit methanol (FM), …
Gc-Ms Analyses And Bioactivities Of Essential Oil Obtained From The Roots Ofchrysopogon Zizanioides (L.) Roberty Cultivated In Giresun, Turkey, Derya Efe, Mustafa Karaköse, Ayça Aktaş Karaçeli̇k, Bengü Ertan, Mehmet Emi̇n Şeker
Gc-Ms Analyses And Bioactivities Of Essential Oil Obtained From The Roots Ofchrysopogon Zizanioides (L.) Roberty Cultivated In Giresun, Turkey, Derya Efe, Mustafa Karaköse, Ayça Aktaş Karaçeli̇k, Bengü Ertan, Mehmet Emi̇n Şeker
Turkish Journal of Chemistry
The essential oils (EOs) constituents have trade importance due to their bioactivities. In this research, the essential oil of the roots of Chrysopogon zizanioides (L.) Roberty cultivated in Giresun was obtained by hydrodistillation. Then, the chemical composition and biological activities of Chrysopogon zizanioides root essential oil (CEO) were studied. Thirty compounds were identified by gas chromatography-mass spectrometry (GC-MS) and the major compounds were determined as isobutyl-angelate (11.15%), α-muurolene (10.56%), α-cedrene (8.42%), α-patchoulene (8.10%), and ethylene brassylate (7.49%). The antimicrobial effect of CEO was investigated against pathogenic bacteria and fungus. Minimal inhibition concentration (MIC) was determined 31.25 μg/mL against C. albicans …
Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Turkish Journal of Chemistry
Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 \textmu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity …
Synthesis, Antioxidant And Antimicrobial Properties Of Novel Pyridyl-Carbonyl Thiazoles As Dendrodoine Analogs, Zafer Şahi̇n, Sevde Nur Bi̇lteki̇n, Leyla Yurttaş, Şeref Demi̇rayak
Synthesis, Antioxidant And Antimicrobial Properties Of Novel Pyridyl-Carbonyl Thiazoles As Dendrodoine Analogs, Zafer Şahi̇n, Sevde Nur Bi̇lteki̇n, Leyla Yurttaş, Şeref Demi̇rayak
Turkish Journal of Chemistry
Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. Structures are elucidated by NMR (1H, 13C) and HRMS spectrums. As an alkaloid derivative, antioxidant properties were evaluated with DPPH and FRAP assays and antimicrobial effect with microdilution method. Among the series, 3bc-3cf showed higher antioxidant activity than those having 3 or 4-pyridyl substituents. There …
Synthesis And Antioxidant, Aggregation, And Electronic Properties Of6-Tert-Butyl-1,4-Benzodioxine Substituted Phthalocyanines, Mehmet Sali̇h Ağirtaş, Beyza Cabi̇r, Selçuk Gümüş, Sadi̇n Özdemi̇r, Abdurrahman Dündar
Synthesis And Antioxidant, Aggregation, And Electronic Properties Of6-Tert-Butyl-1,4-Benzodioxine Substituted Phthalocyanines, Mehmet Sali̇h Ağirtaş, Beyza Cabi̇r, Selçuk Gümüş, Sadi̇n Özdemi̇r, Abdurrahman Dündar
Turkish Journal of Chemistry
As a starting material, 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile was prepared by the reac- tion of 4-tert-butylcatechol with 4,5-dichlorophthalonitrile. Metallophthalocyanine complexes 4-7 were obtained by cyclotetramerization of 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile. All compounds were characterized by elemental analysis and other spectroscopic methods (IR, UV/Vis, and $^{1}$H NMR). Phthalocyanine compounds remained nonaggregated in tetrahydrofuran at the studied concentration ranges. Metallophthalocyanines 4-7 were tested for their antioxidant activities. The antioxidant activity processes included evaluation of radical-scavenging activity, chelat- ing activity, and reducing power. These compounds were compared to standard antioxidant ascorbic acid. The electronic data of the new compounds were obtained by computational …
Synthesis Of 2-Substituted 8-Propargyloxyquinoline Derivatives And Determination Of Their Antioxidant, Antibacterial, And Dna Binding Activities, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Synthesis Of 2-Substituted 8-Propargyloxyquinoline Derivatives And Determination Of Their Antioxidant, Antibacterial, And Dna Binding Activities, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Turkish Journal of Chemistry
2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolines by O-propargylation method (30%-98% yields). The newly synthesized compounds were tested for in vitro antioxidant activities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging (46.5%) and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtained from 6 (72.1%) at the concentration of 500 $\mu $g/mL. To indicate DNA binding activity of the complexes calf thymus DNA was used. The compounds were also evaluated for their antimicrobial activity against three gram-positive and three gram-negative bacteria. Compounds 3 and 5 exhibited antibacterial …
Synthesis And Biological Evaluation Of Quinoline-Triazole And Quinolone-Triazole Conjugates, Ayşegül Gümüş, Veysi̇ Okumuş
Synthesis And Biological Evaluation Of Quinoline-Triazole And Quinolone-Triazole Conjugates, Ayşegül Gümüş, Veysi̇ Okumuş
Turkish Journal of Chemistry
One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b$>$ 3a$>$ 1b} and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 $\mu $g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied …
Synthesis And Evaluation Of Antioxidant Activities Of Novel 1,3,4-Oxadiazole And Imine Containing 1h-Benzimidazoles, Ayşe Selen Alp, Gülgün Kilcigi̇l, Elçi̇n Deni̇z Özdamar, Tülay Çoban, Bi̇nay Eke
Synthesis And Evaluation Of Antioxidant Activities Of Novel 1,3,4-Oxadiazole And Imine Containing 1h-Benzimidazoles, Ayşe Selen Alp, Gülgün Kilcigi̇l, Elçi̇n Deni̇z Özdamar, Tülay Çoban, Bi̇nay Eke
Turkish Journal of Chemistry
Some novel 2-(substitutedbenzylthio)-5-((2-(4-substitutedphenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles (5--12) and 2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N'-(arylmethylene)acetohydrazide derivatives (13--22) were prepared and their in vitro antioxidant properties were investigated by determination of rat liver microsomal NADPH-dependent inhibition of lipid peroxidation (LP) levels and microsomal ethoxyresorufin O-deethylase (EROD) activity. Compound 18 was found to be the most active compound with 100% inhibition on LP level and 92% inhibition on EROD. Compounds 4b, 17, and 19 showed the strongest inhibitory effect (97%) on EROD. The free radical scavenging capacities of the compounds were also tested in vitro determining the interaction of the stable free radical 2,2,diphenyl-1-picrylhydrazyl (DPPH), and compounds 4a and 4b exhibited …
Antioxidant, Anticholinesterase, And Antimicrobial Activities And Fatty Acid Constituents Of Achillea Cappadocica Hausskn. Et Bornm., Abdulselam Ertaş, Mehmet Boğa, Nesri̇n Haşi̇mi̇, Yeter Yeşi̇l, Ahmet Ceyhan Gören, Gülaçti Topçu, Ufuk Kolak
Antioxidant, Anticholinesterase, And Antimicrobial Activities And Fatty Acid Constituents Of Achillea Cappadocica Hausskn. Et Bornm., Abdulselam Ertaş, Mehmet Boğa, Nesri̇n Haşi̇mi̇, Yeter Yeşi̇l, Ahmet Ceyhan Gören, Gülaçti Topçu, Ufuk Kolak
Turkish Journal of Chemistry
This study was the first fatty acid analysis and biological activity report on an endemic Achillea species, Achillea cappadocica Hausskn. et Bornm. The major compounds in the fatty acid were identified as oleic (34.7 %), palmitic (23.1 %), and linoleic acids (20.6 %). The methanol and water extracts indicated higher ABTS cation radical scavenging activity than that of \alpha-tocopherol and BHT at 100 \mu g/mL. The acetone extract showed 70.62 % inhibitory activity against butyrylcholinesterase at 200 \mu g/mL. The acetone and methanol extracts exhibited moderate antimicrobial activity.
Terpenoids, Essential Oil Composition, Fatty Acid Profile, And Biological Activities Of Anatolian Salvia Fruticosa Mill., Gülaçti Topçu, Mehmet Öztürk, Tuba Kuşman, Ayşe Asli Barla Demi̇rkoz, Ufuk Kolak, Ayhan Ulubelen
Terpenoids, Essential Oil Composition, Fatty Acid Profile, And Biological Activities Of Anatolian Salvia Fruticosa Mill., Gülaçti Topçu, Mehmet Öztürk, Tuba Kuşman, Ayşe Asli Barla Demi̇rkoz, Ufuk Kolak, Ayhan Ulubelen
Turkish Journal of Chemistry
The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., afforded 7 diterpenoids (carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool), 4 triterpenoids (\alpha -amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol), a steroid (3-acetylsitosterol), and a flavone (salvigenin). The galls (apples) of the collected plant were separately extracted with hexane to afford fatty acids composed mainly of oleic acid (29\%), palmitoleic acid (29\%), and stearic acid (23.20\%), which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory …
Constituents Of Plantago Major Subsp. Intermedia With Antioxidant And Anticholinesterase Capacities, Ufuk Kolak, Mehmet Boğa, Emi̇ne Akalin Uruşak, Ayhan Ulubelen
Constituents Of Plantago Major Subsp. Intermedia With Antioxidant And Anticholinesterase Capacities, Ufuk Kolak, Mehmet Boğa, Emi̇ne Akalin Uruşak, Ayhan Ulubelen
Turkish Journal of Chemistry
The methanol extract of Plantago major subsp. intermedia (Gilib.) Lange afforded 4 known compounds, namely isomartynoside (1), 10-hydroxymajoroside (2), \beta -sitosterol (3), and ursolic acid (4). Their structures were established by spectroscopic methods. After determination of the total phenolic and flavonoid contents of the methanol extract, the antioxidant potentials of the crude extract and isolated compounds 1-4 were determined by \beta -carotene bleaching, DPPH free radical and ABTS cation radical scavenging, and cupric reducing antioxidant capacity methods. The methanol extract, rich in phenolic contents, indicated the same DPPH free radical scavenging activity (72\% inhibition) as a standard compound, butylated hydroxytoluene, …
Radical Scavenging Potential Of Compounds Isolated From Vitex Agnus-Castus, . Azizuddin, Talat Makhmoor, Muhammad Iqbal Choudhary
Radical Scavenging Potential Of Compounds Isolated From Vitex Agnus-Castus, . Azizuddin, Talat Makhmoor, Muhammad Iqbal Choudhary
Turkish Journal of Chemistry
Nine secondary metabolites-artemetin (1), casticin (2), 3-hydroxy-5,6,7,4'-tetramethoxy flavone U(3), penduletin (4), p-hydroxybenzoic acid (5), methyl 3,4-dihydroxybenzoate (6), methyl isovanillate (7), vanillic acid (8), and 3,4-dihydroxybenzoic acid (9)-were isolated from a folkloric medicinal plant, Vitex agnus-castus. The structures of compounds 1-9 were identified using spectroscopic techniques. Compound 7 was isolated for the first time from this plant. These compounds were screened for their antioxidant activity. Compounds 6 and 9 exhibited significant activity against the DPPH free radical.
Antioxidant Activities Of The Extracts And Components Of Teucrium Orientale L. Var. Orientale, Ahmet Çakir, Ahmet Mavi̇, Cavi̇t Kazaz, Ali̇ Yildirim, Ömer İrfan Küfrevi̇oğlu
Antioxidant Activities Of The Extracts And Components Of Teucrium Orientale L. Var. Orientale, Ahmet Çakir, Ahmet Mavi̇, Cavi̇t Kazaz, Ali̇ Yildirim, Ömer İrfan Küfrevi̇oğlu
Turkish Journal of Chemistry
The effects of the developing stages of Teucrium orientale L. var. orientale on the antioxidant and DPPH radical scavenging activities of the extracts obtained with different organic solvents were investigated. The aerial parts of the plant samples were collected at the budding, flowering and vegetative stages and then the plant samples were extracted separately with petroleum ether, chloroform, acetone and methanol. The antioxidant activities of the extracts were evaluated using 2 different tests: the thiocyanate method and scavenging of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The acetone and methanol extracts of all of the harvesting stages and chloroform extracts of the budding …