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Full-Text Articles in Physical Sciences and Mathematics
Characterization And Purification Of 1,2,4-Triazole-Containing Phthalocyanines Synthesized By Microwave Method And Structure Elucidation By Spectroscopic Techniques, Asi̇ye Nas, Ümi̇t Demi̇rbaş, Nurhan Gümrükçüoğlu, Hali̇t Kanteki̇n
Characterization And Purification Of 1,2,4-Triazole-Containing Phthalocyanines Synthesized By Microwave Method And Structure Elucidation By Spectroscopic Techniques, Asi̇ye Nas, Ümi̇t Demi̇rbaş, Nurhan Gümrükçüoğlu, Hali̇t Kanteki̇n
Turkish Journal of Chemistry
The complexes of peripherally tetra-substituted metal-free (8), lead(II) 9), and zinc(II) (10) phthalocyanine derivatives were synthesized for the first time in this work. The structures of these new complex compounds have been elucidated using many spectral methods such as electronic absorption, FT-IR, $^{1}$H NMR, $^{13}$C NMR, elemental analysis, and mass spectra. The thermogravimetric behavior of compounds 8-10 was determined by thermogravimetric analysis method in addition to these spectral methods.
Synthesis Of Acetamide Derivatives Of 1,2,4-Triazole Bearing Azinane And Their Binding Interactions With Bovine Serum Albumin Using Spectroscopic Techniques, Javed Iqbal, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Hira Khalid, Sabina Jhaumeer Laulloo, Nausheen Joondan, Aniisah Banu Taupass, Shahid Rasool, Syed Adnan Ali Shah
Synthesis Of Acetamide Derivatives Of 1,2,4-Triazole Bearing Azinane And Their Binding Interactions With Bovine Serum Albumin Using Spectroscopic Techniques, Javed Iqbal, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Hira Khalid, Sabina Jhaumeer Laulloo, Nausheen Joondan, Aniisah Banu Taupass, Shahid Rasool, Syed Adnan Ali Shah
Turkish Journal of Chemistry
A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using $^{1}$H NMR, $^{13}$C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bovine serum albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives was evaluated along with thermodynamics, site-selective binding, and synchronous study. The results obtained by BSA binding as well as thermodynamic studies justify that all the compounds show spontaneous interaction with BSA and could be effectively distributed and eliminated from the body. Therefore, the triazole-based analogs might be a useful …
Synthesis And Antimicrobial And Antioxidant Activities Of Hybrid Molecules Containing Benzotriazole And 1,2,4-Triazole, Mahesh Chand, Reena Kaushik, Subhash Chand Jain
Synthesis And Antimicrobial And Antioxidant Activities Of Hybrid Molecules Containing Benzotriazole And 1,2,4-Triazole, Mahesh Chand, Reena Kaushik, Subhash Chand Jain
Turkish Journal of Chemistry
Eleven novel 1,2,4-triazolylbenzotriazoles have been prepared using 1-(hydrazinylcarbonylmethyl)-1$H$-benzot- riazole (3) as a potent intermediate. Compound 3, however, was obtained from benzotriazole in two steps. All synthesized compounds were characterized by detailed spectral studies like IR, $^{1}$H NMR, $^{13}$C NMR, and mass spectrometry. All synthesized compounds were evaluated for their \textit{in vitro} antimicrobial activity against seven strains of bacteria and four strains of fungi. Compounds 13, 17, 19, 20, and 21}were found to possess antibacterial activity comparable to that of ciprofloxacin against a Klebsiella pneumoniae strain. Except for compounds2 and 13, all compounds showed good antifungal activity against an Aspergillus niger …
Synthesis Of Novel 1,2,4-Triazoles And Triazolo-Thiadiazines As Anticancer Agents, Thoraya Abd El-Reheem Farghaly, Magda Ahmad Abdallah, Huda Kamel Mmahmoud
Synthesis Of Novel 1,2,4-Triazoles And Triazolo-Thiadiazines As Anticancer Agents, Thoraya Abd El-Reheem Farghaly, Magda Ahmad Abdallah, Huda Kamel Mmahmoud
Turkish Journal of Chemistry
A new series of 7-arylazo-5$H$-3-(trifluoromethyl)-6-methyl-1,2,4-triazolo-[3,4-$b$]-1,3,4-thiadiazines was prepared by reaction of 4-amino-3-trifluoromethyl-5-mercapto-1,2,4-triazoles with $N$-aryl-2-oxo-propane hydrazonoyl chloride in dioxane under reflux in the presence of triethylamine. Furthermore, Schiff bases of 4-amino-5-mercapto-1,2,4-triazole derivatives were reacted with a variety of hydrazonoyl chlorides and gave the respective hydrazonothioates. In addition, the novel \textit{bis}-(1,2,4-triazole-3-thione) was reacted with the appropriate hydrazonoyl chloride in dioxane under reflux in the presence of triethylamine to give the corresponding \textit{bis}-(1,2,4-triazolethiohydrazonoate). The structures of the new compounds were established based on elemental and spectral data. The mechanism of the studied reaction was also discussed. Moreover, some of the new products were screened …
Synthesis And Characterization Of A Novel 3-Amino-1,2,4-Triazole Lead(Ii) Coordination Polymer, Şebnem Esen Sözerli̇, Arzu Özen, İbrahi̇m Kani̇, Deni̇z Demi̇r
Synthesis And Characterization Of A Novel 3-Amino-1,2,4-Triazole Lead(Ii) Coordination Polymer, Şebnem Esen Sözerli̇, Arzu Özen, İbrahi̇m Kani̇, Deni̇z Demi̇r
Turkish Journal of Chemistry
A novel [Pb_2(\mu-atrz)_2(\mu-CH_3COO)(CH_3COO)]_n (atrz = 3-amino-1,2,4-triazole) complex was synthesized and characterized by IR spectroscopy, thermogravimetric analysis, and single crystal X-ray diffraction. The molecular structure shows that the complex is a coordination polymer in which there are 2 different lead(II) ions with coordination number of 5, Pb(2), and, with a coordination number of 4, Pb(1). Each atrz acts as a bridging ligand between 2 Pb(II) ions through the 2 adjacent nitrogen atoms of the triazole ring. The acetate anions show different types of coordination mode: one acts as a bridge by coordination of the same oxygen atom with Pb(II) ions and …
Synthesis And Antioxidant And Antimicrobial Evaluation Of Novel 4-Substituted-1h-1,2,4-Triazole Derivatives, Sultan Baytaş, Evi̇n Kapçak, Tülay Çoban, Hati̇ce Özbi̇lge
Synthesis And Antioxidant And Antimicrobial Evaluation Of Novel 4-Substituted-1h-1,2,4-Triazole Derivatives, Sultan Baytaş, Evi̇n Kapçak, Tülay Çoban, Hati̇ce Özbi̇lge
Turkish Journal of Chemistry
A series of 4-benzyl/phenyl-3-(1-methyl-1H-indole-2-yl)-1H- 1,2,4-triazole-5(4H)-thione (4a,b) and 2-{4-[benzyl/phenyl-5- (substitutedbenzylthio)]-4H-1,2,4-triazole-3-yl}-1-methyl-1H-indole derivatives (5a-p) were synthesized and evaluated for their in vitro scavenging of DPPH and superoxide radical, and lipid peroxidation inhibition effects as well as their antimicrobial properties. DPPH radical scavenging capacity was found to be equipotent with BHT and found in compounds containing 1,2,4-triazole-5(4H)-thione moiety (4a,b). With regard to antimicrobial properties, compound 5k showed slight antimicrobial activity against all the test microorganisms.
Synthesis Of Linezolid-Like Molecules And Evaluation Of Their Antimicrobial Activities, Serap Başoğlu, Meltem Yolal, Ahmet Demi̇rbaş, Hakan Bektaş, Rza Abbasoğlu, Nesli̇han Demi̇rbaş
Synthesis Of Linezolid-Like Molecules And Evaluation Of Their Antimicrobial Activities, Serap Başoğlu, Meltem Yolal, Ahmet Demi̇rbaş, Hakan Bektaş, Rza Abbasoğlu, Nesli̇han Demi̇rbaş
Turkish Journal of Chemistry
3-Fluoro-4-(morpholin-4-yl)aniline (2), prepared from 3,4-difluoronitrobenzene, was converted to the corresponding Schiff base (3) by treatment with indol-3-carbaldehyde. The treatment of thiourea 4 and carbothioamide derivatives 9 with ethyl bromoacetate or 4-substituted phenacyl bromides generated the corresponding thiazolidinone (5 and 13) and thiazoline (6 and 12) derivatives, respectively. The acidic or basic treatment of carbothioamide 9 produced 1,3,4-thiadiazole (11) or 1,2,4-triazole (10) compounds, respectively. The structural assignments of the new compounds were based on elemental analysis and spectral (IR, ^1H-NMR, ^{13}C-NMR, and LC-MS) data. The antimicrobial activity study revealed that all compounds showed good antitubercular activities.
Preparation And Antimicrobial Activity Evaluation Of Some Quinoline Derivatives Containing An Azole Nucleus, Muhammet Özyanik, Serpi̇l Demi̇rci̇, Hakan Bektaş, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Şengül Alpay Karaoğlu
Preparation And Antimicrobial Activity Evaluation Of Some Quinoline Derivatives Containing An Azole Nucleus, Muhammet Özyanik, Serpi̇l Demi̇rci̇, Hakan Bektaş, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Şengül Alpay Karaoğlu
Turkish Journal of Chemistry
Quinoline-2-carbohydrazide (2) obtained from quinaldic acid (1) was converted to the corresponding carbothioamide 3 and carboxamide 6 by treatment with benzyliso(thio)cyanate. The basic treatment of 3 and 6 yielded the corresponding 1,2,4-triazole derivatives 4 and 7. The synthesis of 5-(quinolin-2-yl)-1,3,4- oxadiazol-2-thiol (9) was performed from the reaction of 1 with CS_2 in basic media. The Mannich reaction of compounds 4, 7, and 9 resulted in the formation of aminoalkylated derivatives 5a-c, 8, and 10a,b. The condensation of 1 with thiosemicarbazide, carbohydrazide, or thiocarbohydrazide gave the corresponding 1,2,4-triazole derivatives (11-13). The treatment of 4-amino-5-(quinolin-2-yl)- 4H-1,2,4-triazole-3-thiol (13) with 4-chlorophenacyl bromide caused the …
Synthesis, Characterization, And Antioxidant Activities Of New Trisubstituted Triazoles, Kemal Sancak, Yasemi̇n Ünver, Di̇lek Ünlüer, Esra Düğdü, Gülcan Kör, Fati̇h Çeli̇k, Emrah Bi̇ri̇nci̇
Synthesis, Characterization, And Antioxidant Activities Of New Trisubstituted Triazoles, Kemal Sancak, Yasemi̇n Ünver, Di̇lek Ünlüer, Esra Düğdü, Gülcan Kör, Fati̇h Çeli̇k, Emrah Bi̇ri̇nci̇
Turkish Journal of Chemistry
A series of new 4-(3,4dimethoxyphenethyl)-3,5-akyl/aryl-4H- 1,2,4-triazoles (3a-g) were obtained by reaction of ethyl N'-(alkylidene/arylidene)hydrazonate (1) and 2-(3,4-dimethoxy phenyl)ethanamine (2). Compounds 4d, e, and g were synthesized from the reaction of corresponding compounds 3d, e, and g with BBr_3, respectively. The 10 new compounds synthesized were characterized by elemental analyses, IR, ^1H-NMR, and ^{13}C-NMR spectral data. The structure of compound 3g was inferred through IR, ^1H-, ^{13}C-NMR, elemental analyses, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antioxidant properties. Among the chemicals tested, 4d, e, and g exhibited the highest degree of antioxidant activity.
Synthesis And Antimicrobial Activities Of Some New 1,2,4-Triazole Derivatives, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Hacer Bayrak, Hakan Bektaş, Şengül Alpay Karaoğlu
Synthesis And Antimicrobial Activities Of Some New 1,2,4-Triazole Derivatives, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Hacer Bayrak, Hakan Bektaş, Şengül Alpay Karaoğlu
Turkish Journal of Chemistry
The synthesis of ethyl [3-(cyanomethyl)-5-alkyl-4H-1,2,4-triazol- 4-yl]carbamates (2a-d) was performed starting from ethyl 2-[ethoxy(4- (aryl)methylene]hydrazinecarboxylates (1a, 1b). The treatment of 2a with thiosemicarbazide afforded ethyl [3-[(5-amino-1,3,4-thiadiazol- 2-yl)methyl]-5-(4-nitrophenyl)-4H-1,2,4-triazol-4-yl]carbamates (3a), whereas compound 2b produced 5-{[4-amino-5-(4-methylphenyl)- 4H-1,2,4-triazol-3-yl]methyl}-1,3,4-thiadiazol-2-amine (3b) in the same reaction conditions. The treatment of tert-butyl 2-[2-(4-chlorophenyl)-1-ethoxyethylidene]hydrazinecarboxylate (5) with malonohydrazide or cyanoacethydrazide gave the corresponding 1,2,4-triazol-ylcarbamate derivatives (6 or 9); then the hydrolysis of these compounds resulted in the formation of 3-{[4-amino-5-(4- chlorobenzyl)-4H-1,2,4-triazol-3-yl]methyl}-5-(4-chlorobenzyl)-4H- 1,2,4-triazol-4-amine (7) and [4-amino-5-(4-chlorobenzyl)-4H- 1,2,4-triazole-3-yl]acetonitrile (10), respectively. The synthesis of the Schiff base derivatives 3-(4-chlorobenzyl)-5-{[5-(4-chloroben- zyl)-4-[(2-hydroxyphenyl-methylene)amino]-4H-1,2,4-triazol-3-yl]methyl} -N-(2-hydroxyphenylmethylene)-4H-1,2,4-triazol-4-amine (8), and (5-(4-chlorobenzyl)-4-{[(2,6-dichlorophenyl)methylene]amino}-4H-1,2,4- triazol-3-yl)acetonitrile (12) was performed from the reaction of compounds 7 …
Synthesis And Antimicrobial Activities Of Some New Biheterocyclic Compounds Containing 1,2,4-Triazol-3-One And 1,3,4-Thiadiazole Moieties, Ahmet Demi̇rbaş, Nesli̇han Demi̇rbaş, Hakan Bektaş, Hacer Bayrak, Şengül Alpay Karaoğlu
Synthesis And Antimicrobial Activities Of Some New Biheterocyclic Compounds Containing 1,2,4-Triazol-3-One And 1,3,4-Thiadiazole Moieties, Ahmet Demi̇rbaş, Nesli̇han Demi̇rbaş, Hakan Bektaş, Hacer Bayrak, Şengül Alpay Karaoğlu
Turkish Journal of Chemistry
2-(4-Amino-3-(4-chlorophenyl)-5-oxo-4,5--dihydro-1H-1,2,4-triazol- 1-yl)-N'-[(2,6-dihalogenophenyl)-methylene]acetohydrazides (3a,b) was obtained via the formation of 2-(4-amino-3-(4-chlorophenyl)-5-oxo-4,5- dihydro-1H-1,2,4-triazol-1-yl)acetohydrazide (2), which was obtained starting from 4-amino-5-(4-chlo\-rophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (1) in 2 steps. 2-{[4-amino-3-(4-chlorophenyl)-5-oxo-4,5--dihydro-1H- 1,2,4-triazol-1-yl]acetyl}-N-phenylhydra-zine carbothioamide (4), which was prepared starting from 2, was converted to the corresponding 1,3,4-thiadiazole derivative (5) in acidic media. Moreover, the basic treatment of 4 resulted in the formation of 4-amino-5-(4-chlorophenyl)- 2-[(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2,4- dihydro-3H-1,2,4-triazol-3-one (7). The reactions of compounds 5 and 7 with methyl iodide in the presence of sodium ethoxide afforded the corresponding N-methyl (6) and S-methyl (8) derivatives, respectively. The synthesis of Mannich bases (10a and 10b) was performed from the reaction of 7 with …
Synthesis And Characterizations Of Some New 4h-1,2,4-Triazole Derivatives, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Şule Ceylan, Deni̇z Şahi̇n
Synthesis And Characterizations Of Some New 4h-1,2,4-Triazole Derivatives, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Şule Ceylan, Deni̇z Şahi̇n
Turkish Journal of Chemistry
3-[(5-Amino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-alkyl-4H-1,2,4-triazoles (2a,b) were obtained from the reaction of 3-cyanomethyl-5-alkyl-4-ethoxycarbonylamino-4H-1,2,4-triazoles (1a,b) with thiosemicarbazide in the presence of trifluoroacetic acid. The treatment of the obtained compounds (2a,b) with acetic anhydride for 1 h afforded 3-[(5-acetylamino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-alkyl-4H-1,2,4-triazoles (3a,b). The synthesis of 4-ethoxycarbonylamino-3-[(2,3-dihydro-1,3-benzoxazol-2-yl)methyl]-5-(4-methylbenzyl)-4H-1,2,4-triazole (4) was performed by the treatment of 3-[(5-acetylamino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-(4-methylbenzyl)-4H-1,2,4-triazole (3a) with o-aminophenol under nitrogen atmosphere for 50 h. The reaction of compounds 1a,b with salicylaldehyde in the presence of sodium ethoxide yielded 2-{4-[(ethoxycarbonyl)amino]-5-alkyl-4H-1,2,4-triazol-3-yl}-3-(2-hydroxyphenyl)-acrylonitriles (5a,b). The acetylations of compounds 5a,b with acetic anhydride for 5 h resulted in the formation of 2-{4-[acetyl(ethoxycarbonyl)amino]-5-alkyl-4H-1,2,4-triazol-3-yl}-3-[2-(acetyloxy)phenyl]-acrylic acids (6a,b). On the other hand, the treatment of compounds 5a,b with …
Synthesis Of Some Novel 3,5-Diaryl-1,2,4-Triazole Derivatives And Investigation Of Their Antimicrobial Activities, Mevlut Serdar, Nurhan Gümrükçüoğlu, Şengül Alpay Karaoğlu, Nesli̇han Demi̇rbaş
Synthesis Of Some Novel 3,5-Diaryl-1,2,4-Triazole Derivatives And Investigation Of Their Antimicrobial Activities, Mevlut Serdar, Nurhan Gümrükçüoğlu, Şengül Alpay Karaoğlu, Nesli̇han Demi̇rbaş
Turkish Journal of Chemistry
A series of acylhydrazones (2a-d) was synthesized from the reactions of iminoester hydrochlorides (1a-e) with acyl hydrazines. 2,5-Dialkyl 1,3,4-oxadiazoles (3a-d) were obtained in the same reaction media. The treatment of acylhydrazones with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4-triazoles (4a-c). The acetylation of 4-amino-3-(4-hydroxyphenyl)-5-phenyl-4H-1,2,4-triazole (4a) produced 4-amino-5-(4-acetoxyphenyl)-3-phenyl-4H-1,2,4-triazole (9), while the acetylation of 4-amino-3-(4-tolyl)-5-phenyl-4H-1,2,4-triazole (4b) gave 4-acetylamino-3-phenyl-5-(4-tolyl)-4H-1,2,4-triazole (10). The treatment of compound 4b with various aromatic aldehydes or acetophenone and 4-nitroacetophenone resulted in the formation of 4-arylidenamino-3,5-dialkyl-4H-1,2,4-triazoles (5a-e and 7a,b). Sodium borohydride reduction of 4-arylidenamino derivatives of 1,2,4-triazoles afforded 4-alkylamino-3,5-dialkyl-4H-1,2,4-triazoles (6a-e and 8a,b). All newly synthesized compounds were screened for their antimicrobial and antifungal …
Synthesis And Antimicrobial Activities Of Some New 1,2,4-Triazole Derivatives, Nurhan Gümrükçüoğlu, Mevlut Serdar, Eli̇f Çeli̇k, Ali̇ Sevi̇m, Nesli̇han Demi̇rbaş
Synthesis And Antimicrobial Activities Of Some New 1,2,4-Triazole Derivatives, Nurhan Gümrükçüoğlu, Mevlut Serdar, Eli̇f Çeli̇k, Ali̇ Sevi̇m, Nesli̇han Demi̇rbaş
Turkish Journal of Chemistry
A series of acylhydrazones (2a-f) were synthesized by the condensation of iminoester hydrochlorides (1a-f) with acyl hydrazines. 2,5-Dialkyl 1,3,4-oxadiazoles (3a,c,e) were obtained in the same reaction media. The treatment of acylhydrazones with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4-triazoles (4a-c). The acetylation of 4-amino-3,5-dialkyl-1,2,4-triazoles produced N-[3,5-dialkyl-4H-1,2,4-triazol-4-yl] acetamides (5-7). The treatment of compounds 4a and 4c with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3,5-dialkyl-1,2,4-triazoles (8a,d, e, and 10a-e). Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3,5-dialkyl-1,2,4-triazoles (9a,d, e, and 11a-e). Compounds 4b, 4c, 7, 8d, and 11c showed good antifungal activity only against yeast-like fungi, while compounds 3e, 6, 8e, and 9e …
Synthesis And Characterization Of Some 3-Alkyl-4-Amino-5-Cyanomethyl-4h-1,2,4-Triazoles, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Kemal Sancak
Synthesis And Characterization Of Some 3-Alkyl-4-Amino-5-Cyanomethyl-4h-1,2,4-Triazoles, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Kemal Sancak
Turkish Journal of Chemistry
The preparation and characterization of some 3-alkyl-4-amino-5-cyanomethyl-4H-1,2,4-triazoles with active methylene groups are described and their structural properties using NMR and IR spectra and elemental analyses are given.