Physical Sciences and Mathematics Commons^™

Comparative Molecular Field Analysis (Comfa) Of Phenyl Ring Substituted Methylphenidates, Milind Misra

Theses

Comparative Molecular Field Analysis (CoMFA) was performed on 30 methylphenidate analogues having phenyl ring substituents at the 2-, 3-, and 4-positions in an attempt to explain the structure-activity relationships of the analogues. Several CoMFA studies were carried out using different conformations of methylphenidate as the template structures for the corresponding alignment rules. The identification of the bioactive conformation was variously based on the interfeature distances in WIN 35,428, on cluster analysis, and on a comparison of active methylphenidate analogues. The sensitivity of the models to various CoMFA parameters was compared. These parameters included altering the size and spacing of the …

Catalyctic Reduction Of Nitric Oxide By Copper Catalyzed Granular Activated Carbon In The Presence Of Oxygen, Shan Xiao

Theses

The catalytic reduction of nitric oxides by solid carbonaceous material consisting primarily of granular activated carbon or (GAC) was studied in a fix bed catalytic reactor in order to develop the technology for removing NO and soot simultaneously from diesel engine exhaust. The catalytic activity and conversion of NO as a function of reaction temperature was evaluated as a function of space velocity. The results show that at lean condition and high gaseous hourly space velocity, vis., 50,000 ~ 80,000, Cu-ZSM-5 does not perform as well with CO and GAC as it does with gaseous hydrocarbons(HC). Plain GAC has low …

Sustainable Green Manufacturing Of Energetic Materials, Ted Alex Formeza

Theses

Pollution from manufacturing processes of the major energetic materials currently used in the U.S., 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX), 1,3,5,7-tetranitro-1,3,5,7 tetraazacyclooctane (HMX) was briefly evaluated. It was found that acetic acid was a major pollutant. It appeared that the British Process could be controlled to reduce the polluting effluents better than the Bachmann Process used in the U.S. Most of the effort for producing the next generation of energetic materials is currently centered around the production of 1,3,3-trinitroazetidine (TNAZ). We evaluated five synthetic routes for producing TNAZ. We reduced the number of potential processes by carefully considering possible changes in the schemes that …

Role Of Zeta Potential In Micro-Carrier Process, Pallavi Mehta

Theses

The micro-carrier process recently developed at NJIT is a new high rate settling technology for water and wastewater treatment. This process utilizes the micro-cater as a flocculating enhancement agent to achieve rapid removal of colloidal particles. This thesis consist of two parts, namely, 1) A review of the flocculation process utilized in water and wastewater treatment, and 2) An experimental program to evaluate the role of zeta potential in the flocculation process.

The results of this study indicated that the DLVO theory (Darjaguin, Landau, Overbeek, Verwey theory) is applicable to micro-cater process in the absence of polyelectrolytes. The best flocculation …

Characterisation And Optimisation Of Gypsum Crystallization, Catherine H. Shannon

Theses

Gypsum is produced as a by-product during the citric acid production process at ADM Ringaskiddy. The particle size and filterability of the gypsum has a critical bearing on the overall citric acid production rate. Prior to August 1996, research in the area of gypsum crystal optimisation at ADM had concentrated on the application of vortex mixing to perform the gypsum formation reaction. While the gypsum crystals produced with vortex mixing were found to be desirably clear of microcrystalline gypsum, the crystals were considerably smaller and more difficult to filter and wash. This research project sought to retain the advantages conferred …

New Polyether Toxins From Shellfish And Marine Phytoplankton: Isolation Studies And Development Of Analytical Methods, Alan G. Bishop

Theses

There are three classes of polyether toxins responsible for Diarrhetic Shellfish Poisoning (DSP) world-wide. The causative toxins are okadaic acid (OA) and derivatives (DTXs), pectenotoxins (PTXs) and yessotoxins (YTXs). The origin of these toxins are phytoplankton from Dinophysis or Prorocentrum spp. OA has been demonstrated for most outbreaks in Europe and more recently a new isomer DTX-2 has been reported in Ireland.

Marine phytoplankton biomass samples consisting predominantly of Dinophysis acuta, were acquired using a large double plankton net from waters off the South-west coast of Ireland. Analysis of unialgal samples using high performance liquid chromatography (HPLC) with fluorescence and …

Optimisation Studies In A Batch Pharmaceutical Company, Sarah Fitzgerald

Theses

This thesis outlines a collaborative project between industry and academia based on a short term research contract.

In the past in Eli Lilly, process optimisation in a multi-purpose, modular building had been mainly confined to equipment commissioning and new product development. It was necessary to embark upon an exercise to develop an optimisation programme m order to meet the increased requirements and demands of the building. Increased market demands, through the introduction of over-the-counter (OTC) drugs, and the demand for cycle time reduction through the expiry of existing patents, made the need for optimisation inevitable.

The purpose of this thesis …